The Agonist Action of Alkylphenols on TRPA1 Relates to Their Effects on Membrane Lipid Order: Implications for TRPA1-Mediated Chemosensation

The Transient Receptor Potential Ankyrin 1 cation channel (TRPA1) is a broadly-tuned chemosensor expressed in nociceptive neurons. Multiple TRPA1 agonists are chemically unrelated non-electrophilic compounds, for which the mechanisms of channel activation remain unknown. Here, we assess the hypothes...

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Detalles Bibliográficos
Autores principales: Startek, Justyna B., Milici, Alina, Naert, Robbe, Segal, Andrei, Alpizar, Yeranddy A., Voets, Thomas, Talavera, Karel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037438/
https://www.ncbi.nlm.nih.gov/pubmed/33806007
http://dx.doi.org/10.3390/ijms22073368

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