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Superoxide Dismutase Administration: A Review of Proposed Human Uses
Superoxide dismutases (SODs) are metalloenzymes that play a major role in antioxidant defense against oxidative stress in the body. SOD supplementation may therefore trigger the endogenous antioxidant machinery for the neutralization of free-radical excess and be used in a variety of pathological se...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037464/ https://www.ncbi.nlm.nih.gov/pubmed/33805942 http://dx.doi.org/10.3390/molecules26071844 |
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author | Rosa, Arianna Carolina Corsi, Daniele Cavi, Niccolò Bruni, Natascia Dosio, Franco |
author_facet | Rosa, Arianna Carolina Corsi, Daniele Cavi, Niccolò Bruni, Natascia Dosio, Franco |
author_sort | Rosa, Arianna Carolina |
collection | PubMed |
description | Superoxide dismutases (SODs) are metalloenzymes that play a major role in antioxidant defense against oxidative stress in the body. SOD supplementation may therefore trigger the endogenous antioxidant machinery for the neutralization of free-radical excess and be used in a variety of pathological settings. This paper aimed to provide an extensive review of the possible uses of SODs in a range of pathological settings, as well as describe the current pitfalls and the delivery strategies that are in development to solve bioavailability issues. We carried out a PubMed query, using the keywords “SOD”, “SOD mimetics”, “SOD supplementation”, which included papers published in the English language, between 2012 and 2020, on the potential therapeutic applications of SODs, including detoxification strategies. As highlighted in this paper, it can be argued that the generic antioxidant effects of SODs are beneficial under all tested conditions, from ocular and cardiovascular diseases to neurodegenerative disorders and metabolic diseases, including diabetes and its complications and obesity. However, it must be underlined that clinical evidence for its efficacy is limited and consequently, this efficacy is currently far from being demonstrated. |
format | Online Article Text |
id | pubmed-8037464 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80374642021-04-12 Superoxide Dismutase Administration: A Review of Proposed Human Uses Rosa, Arianna Carolina Corsi, Daniele Cavi, Niccolò Bruni, Natascia Dosio, Franco Molecules Review Superoxide dismutases (SODs) are metalloenzymes that play a major role in antioxidant defense against oxidative stress in the body. SOD supplementation may therefore trigger the endogenous antioxidant machinery for the neutralization of free-radical excess and be used in a variety of pathological settings. This paper aimed to provide an extensive review of the possible uses of SODs in a range of pathological settings, as well as describe the current pitfalls and the delivery strategies that are in development to solve bioavailability issues. We carried out a PubMed query, using the keywords “SOD”, “SOD mimetics”, “SOD supplementation”, which included papers published in the English language, between 2012 and 2020, on the potential therapeutic applications of SODs, including detoxification strategies. As highlighted in this paper, it can be argued that the generic antioxidant effects of SODs are beneficial under all tested conditions, from ocular and cardiovascular diseases to neurodegenerative disorders and metabolic diseases, including diabetes and its complications and obesity. However, it must be underlined that clinical evidence for its efficacy is limited and consequently, this efficacy is currently far from being demonstrated. MDPI 2021-03-25 /pmc/articles/PMC8037464/ /pubmed/33805942 http://dx.doi.org/10.3390/molecules26071844 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Review Rosa, Arianna Carolina Corsi, Daniele Cavi, Niccolò Bruni, Natascia Dosio, Franco Superoxide Dismutase Administration: A Review of Proposed Human Uses |
title | Superoxide Dismutase Administration: A Review of Proposed Human Uses |
title_full | Superoxide Dismutase Administration: A Review of Proposed Human Uses |
title_fullStr | Superoxide Dismutase Administration: A Review of Proposed Human Uses |
title_full_unstemmed | Superoxide Dismutase Administration: A Review of Proposed Human Uses |
title_short | Superoxide Dismutase Administration: A Review of Proposed Human Uses |
title_sort | superoxide dismutase administration: a review of proposed human uses |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037464/ https://www.ncbi.nlm.nih.gov/pubmed/33805942 http://dx.doi.org/10.3390/molecules26071844 |
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