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Superoxide Dismutase Administration: A Review of Proposed Human Uses

Superoxide dismutases (SODs) are metalloenzymes that play a major role in antioxidant defense against oxidative stress in the body. SOD supplementation may therefore trigger the endogenous antioxidant machinery for the neutralization of free-radical excess and be used in a variety of pathological se...

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Autores principales: Rosa, Arianna Carolina, Corsi, Daniele, Cavi, Niccolò, Bruni, Natascia, Dosio, Franco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037464/
https://www.ncbi.nlm.nih.gov/pubmed/33805942
http://dx.doi.org/10.3390/molecules26071844
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author Rosa, Arianna Carolina
Corsi, Daniele
Cavi, Niccolò
Bruni, Natascia
Dosio, Franco
author_facet Rosa, Arianna Carolina
Corsi, Daniele
Cavi, Niccolò
Bruni, Natascia
Dosio, Franco
author_sort Rosa, Arianna Carolina
collection PubMed
description Superoxide dismutases (SODs) are metalloenzymes that play a major role in antioxidant defense against oxidative stress in the body. SOD supplementation may therefore trigger the endogenous antioxidant machinery for the neutralization of free-radical excess and be used in a variety of pathological settings. This paper aimed to provide an extensive review of the possible uses of SODs in a range of pathological settings, as well as describe the current pitfalls and the delivery strategies that are in development to solve bioavailability issues. We carried out a PubMed query, using the keywords “SOD”, “SOD mimetics”, “SOD supplementation”, which included papers published in the English language, between 2012 and 2020, on the potential therapeutic applications of SODs, including detoxification strategies. As highlighted in this paper, it can be argued that the generic antioxidant effects of SODs are beneficial under all tested conditions, from ocular and cardiovascular diseases to neurodegenerative disorders and metabolic diseases, including diabetes and its complications and obesity. However, it must be underlined that clinical evidence for its efficacy is limited and consequently, this efficacy is currently far from being demonstrated.
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spelling pubmed-80374642021-04-12 Superoxide Dismutase Administration: A Review of Proposed Human Uses Rosa, Arianna Carolina Corsi, Daniele Cavi, Niccolò Bruni, Natascia Dosio, Franco Molecules Review Superoxide dismutases (SODs) are metalloenzymes that play a major role in antioxidant defense against oxidative stress in the body. SOD supplementation may therefore trigger the endogenous antioxidant machinery for the neutralization of free-radical excess and be used in a variety of pathological settings. This paper aimed to provide an extensive review of the possible uses of SODs in a range of pathological settings, as well as describe the current pitfalls and the delivery strategies that are in development to solve bioavailability issues. We carried out a PubMed query, using the keywords “SOD”, “SOD mimetics”, “SOD supplementation”, which included papers published in the English language, between 2012 and 2020, on the potential therapeutic applications of SODs, including detoxification strategies. As highlighted in this paper, it can be argued that the generic antioxidant effects of SODs are beneficial under all tested conditions, from ocular and cardiovascular diseases to neurodegenerative disorders and metabolic diseases, including diabetes and its complications and obesity. However, it must be underlined that clinical evidence for its efficacy is limited and consequently, this efficacy is currently far from being demonstrated. MDPI 2021-03-25 /pmc/articles/PMC8037464/ /pubmed/33805942 http://dx.doi.org/10.3390/molecules26071844 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Rosa, Arianna Carolina
Corsi, Daniele
Cavi, Niccolò
Bruni, Natascia
Dosio, Franco
Superoxide Dismutase Administration: A Review of Proposed Human Uses
title Superoxide Dismutase Administration: A Review of Proposed Human Uses
title_full Superoxide Dismutase Administration: A Review of Proposed Human Uses
title_fullStr Superoxide Dismutase Administration: A Review of Proposed Human Uses
title_full_unstemmed Superoxide Dismutase Administration: A Review of Proposed Human Uses
title_short Superoxide Dismutase Administration: A Review of Proposed Human Uses
title_sort superoxide dismutase administration: a review of proposed human uses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037464/
https://www.ncbi.nlm.nih.gov/pubmed/33805942
http://dx.doi.org/10.3390/molecules26071844
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