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In Silico Design and Selection of New Tetrahydroisoquinoline-Based CD44 Antagonist Candidates

CD44 promotes metastasis, chemoresistance, and stemness in different types of cancer and is a target for the development of new anti-cancer therapies. All CD44 isoforms share a common N-terminal domain that binds to hyaluronic acid (HA). Herein, we used a computational approach to design new potenti...

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Detalles Bibliográficos
Autores principales:	Ruiz-Moreno, Angel J., Reyes-Romero, Atilio, Dömling, Alexander, Velasco-Velázquez, Marco A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037692/ https://www.ncbi.nlm.nih.gov/pubmed/33810348 http://dx.doi.org/10.3390/molecules26071877

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