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Epidemiology and Viral Etiology of Pediatric Immune Thrombocytopenia through Korean Public Health Data Analysis

Immune thrombocytopenic purpura (ITP) is prevalent in children aged 2–5 years but may occur in all pediatric age groups. In 50–60% of pediatric patients, ITP is preceded by an upper respiratory tract infection 1–4 weeks before its onset. In this study, the relationship between the development of ITP...

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Autores principales: Lim, Jae Hee, Kim, Yu Kyeong, Min, So Hyeon, Kim, Sang Won, Lee, Young Hwan, Lee, Jae Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037772/
https://www.ncbi.nlm.nih.gov/pubmed/33806145
http://dx.doi.org/10.3390/jcm10071356
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author Lim, Jae Hee
Kim, Yu Kyeong
Min, So Hyeon
Kim, Sang Won
Lee, Young Hwan
Lee, Jae Min
author_facet Lim, Jae Hee
Kim, Yu Kyeong
Min, So Hyeon
Kim, Sang Won
Lee, Young Hwan
Lee, Jae Min
author_sort Lim, Jae Hee
collection PubMed
description Immune thrombocytopenic purpura (ITP) is prevalent in children aged 2–5 years but may occur in all pediatric age groups. In 50–60% of pediatric patients, ITP is preceded by an upper respiratory tract infection 1–4 weeks before its onset. In this study, the relationship between the development of ITP and viral infections in children was assessed. We analyzed data of 6487 patients aged < 18 years with incident ITP from the Health Insurance Review and Assessment Open Access Big Data Platform (2015 to 2018) and the Korea Disease Control and Prevention Agency. The monthly positive detection rate (PDR) of seven respiratory and four acute diarrhea viruses was calculated. The virus PDR seasonal trend data was analyzed through ARIMA modeling. The ITP diagnostic data and prevalence of viral infection 1 and 2 months prior were analyzed using the Granger test. The overall male to female (M/F) ratio was 1.2, whereas it was 1.4 in the youngest age group (< 1 year). The overall ITP incidence rate was 18.1 per 100,000 person-years. Respiratory syncytial virus, rhinovirus, rotavirus, and astrovirus infections influenced ITP occurrence in children. However, rotavirus infection is positively associated with the etiology of ITP after 1–2 months.
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spelling pubmed-80377722021-04-12 Epidemiology and Viral Etiology of Pediatric Immune Thrombocytopenia through Korean Public Health Data Analysis Lim, Jae Hee Kim, Yu Kyeong Min, So Hyeon Kim, Sang Won Lee, Young Hwan Lee, Jae Min J Clin Med Article Immune thrombocytopenic purpura (ITP) is prevalent in children aged 2–5 years but may occur in all pediatric age groups. In 50–60% of pediatric patients, ITP is preceded by an upper respiratory tract infection 1–4 weeks before its onset. In this study, the relationship between the development of ITP and viral infections in children was assessed. We analyzed data of 6487 patients aged < 18 years with incident ITP from the Health Insurance Review and Assessment Open Access Big Data Platform (2015 to 2018) and the Korea Disease Control and Prevention Agency. The monthly positive detection rate (PDR) of seven respiratory and four acute diarrhea viruses was calculated. The virus PDR seasonal trend data was analyzed through ARIMA modeling. The ITP diagnostic data and prevalence of viral infection 1 and 2 months prior were analyzed using the Granger test. The overall male to female (M/F) ratio was 1.2, whereas it was 1.4 in the youngest age group (< 1 year). The overall ITP incidence rate was 18.1 per 100,000 person-years. Respiratory syncytial virus, rhinovirus, rotavirus, and astrovirus infections influenced ITP occurrence in children. However, rotavirus infection is positively associated with the etiology of ITP after 1–2 months. MDPI 2021-03-25 /pmc/articles/PMC8037772/ /pubmed/33806145 http://dx.doi.org/10.3390/jcm10071356 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Lim, Jae Hee
Kim, Yu Kyeong
Min, So Hyeon
Kim, Sang Won
Lee, Young Hwan
Lee, Jae Min
Epidemiology and Viral Etiology of Pediatric Immune Thrombocytopenia through Korean Public Health Data Analysis
title Epidemiology and Viral Etiology of Pediatric Immune Thrombocytopenia through Korean Public Health Data Analysis
title_full Epidemiology and Viral Etiology of Pediatric Immune Thrombocytopenia through Korean Public Health Data Analysis
title_fullStr Epidemiology and Viral Etiology of Pediatric Immune Thrombocytopenia through Korean Public Health Data Analysis
title_full_unstemmed Epidemiology and Viral Etiology of Pediatric Immune Thrombocytopenia through Korean Public Health Data Analysis
title_short Epidemiology and Viral Etiology of Pediatric Immune Thrombocytopenia through Korean Public Health Data Analysis
title_sort epidemiology and viral etiology of pediatric immune thrombocytopenia through korean public health data analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037772/
https://www.ncbi.nlm.nih.gov/pubmed/33806145
http://dx.doi.org/10.3390/jcm10071356
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