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CRISPR Screens in Synthetic Lethality and Combinatorial Therapies for Cancer

SIMPLE SUMMARY: The synthetic lethality (SL) clinical success of PARP inhibitors in homologous recombinant deficient tumors has established a new concept for cancer treatment. For decades, efforts have centered on identifying genetic interactions for determining essential tumoral genes, and more rec...

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Detalles Bibliográficos
Autores principales:	Castells-Roca, Laia, Tejero, Eudald, Rodríguez-Santiago, Benjamín, Surrallés, Jordi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037779/ https://www.ncbi.nlm.nih.gov/pubmed/33808217 http://dx.doi.org/10.3390/cancers13071591

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