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Poly(chitosan-ester-ether-urethane) Hydrogels as Highly Controlled Genistein Release Systems

Polymeric hydrogels play an increasingly important role in medicine, pharmacy and cosmetology. They appear to be one of the most promising groups of biomaterials due to their favorable physicochemical properties and biocompatibility. The objective of the presented study was to synthesize new poly(ch...

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Autores principales: Zagórska-Dziok, Martyna, Kleczkowska, Patrycja, Olędzka, Ewa, Figat, Ramona, Sobczak, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037816/
https://www.ncbi.nlm.nih.gov/pubmed/33805204
http://dx.doi.org/10.3390/ijms22073339
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author Zagórska-Dziok, Martyna
Kleczkowska, Patrycja
Olędzka, Ewa
Figat, Ramona
Sobczak, Marcin
author_facet Zagórska-Dziok, Martyna
Kleczkowska, Patrycja
Olędzka, Ewa
Figat, Ramona
Sobczak, Marcin
author_sort Zagórska-Dziok, Martyna
collection PubMed
description Polymeric hydrogels play an increasingly important role in medicine, pharmacy and cosmetology. They appear to be one of the most promising groups of biomaterials due to their favorable physicochemical properties and biocompatibility. The objective of the presented study was to synthesize new poly(chitosan-ester-ether-urethane) hydrogels and to study the kinetic release of genistein (GEN) from these biomaterials. In view of the above, six non-toxic hydrogels were synthesized via the Ring-Opening Polymerization (ROP) and polyaddition processes. The poly(ester-ether) components of the hydrogels have been produced in the presence of the enzyme as a biocatalyst. In some cases, the in vitro release rate of GEN from the obtained hydrogels was characterized by near-zero-order kinetics, without “burst release” and with non-Fickian transport. It is important to note that developed hydrogels have been shown to possess the desired safety profile due to lack of cytotoxicity to skin cells (keratinocytes and fibroblasts). Taking into account the non-toxicity of hydrogels and the relatively highly controlled release profile of GEN, these results may provide fresh insight into polymeric hydrogels as an effective dermatological and/or cosmetological tool.
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spelling pubmed-80378162021-04-12 Poly(chitosan-ester-ether-urethane) Hydrogels as Highly Controlled Genistein Release Systems Zagórska-Dziok, Martyna Kleczkowska, Patrycja Olędzka, Ewa Figat, Ramona Sobczak, Marcin Int J Mol Sci Article Polymeric hydrogels play an increasingly important role in medicine, pharmacy and cosmetology. They appear to be one of the most promising groups of biomaterials due to their favorable physicochemical properties and biocompatibility. The objective of the presented study was to synthesize new poly(chitosan-ester-ether-urethane) hydrogels and to study the kinetic release of genistein (GEN) from these biomaterials. In view of the above, six non-toxic hydrogels were synthesized via the Ring-Opening Polymerization (ROP) and polyaddition processes. The poly(ester-ether) components of the hydrogels have been produced in the presence of the enzyme as a biocatalyst. In some cases, the in vitro release rate of GEN from the obtained hydrogels was characterized by near-zero-order kinetics, without “burst release” and with non-Fickian transport. It is important to note that developed hydrogels have been shown to possess the desired safety profile due to lack of cytotoxicity to skin cells (keratinocytes and fibroblasts). Taking into account the non-toxicity of hydrogels and the relatively highly controlled release profile of GEN, these results may provide fresh insight into polymeric hydrogels as an effective dermatological and/or cosmetological tool. MDPI 2021-03-24 /pmc/articles/PMC8037816/ /pubmed/33805204 http://dx.doi.org/10.3390/ijms22073339 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Zagórska-Dziok, Martyna
Kleczkowska, Patrycja
Olędzka, Ewa
Figat, Ramona
Sobczak, Marcin
Poly(chitosan-ester-ether-urethane) Hydrogels as Highly Controlled Genistein Release Systems
title Poly(chitosan-ester-ether-urethane) Hydrogels as Highly Controlled Genistein Release Systems
title_full Poly(chitosan-ester-ether-urethane) Hydrogels as Highly Controlled Genistein Release Systems
title_fullStr Poly(chitosan-ester-ether-urethane) Hydrogels as Highly Controlled Genistein Release Systems
title_full_unstemmed Poly(chitosan-ester-ether-urethane) Hydrogels as Highly Controlled Genistein Release Systems
title_short Poly(chitosan-ester-ether-urethane) Hydrogels as Highly Controlled Genistein Release Systems
title_sort poly(chitosan-ester-ether-urethane) hydrogels as highly controlled genistein release systems
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037816/
https://www.ncbi.nlm.nih.gov/pubmed/33805204
http://dx.doi.org/10.3390/ijms22073339
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