Antimicrobial Hexaaquacopper(II) Complexes with Novel Polyiodide Chains

The non-toxic inorganic antimicrobial agents iodine (I(2)) and copper (Cu) are interesting alternatives for biocidal applications. Iodine is broad-spectrum antimicrobial agent but its use is overshadowed by compound instability, uncontrolled iodine release and short-term effectiveness. These disadvantages can be reduced by forming complex-stabilized, polymeric polyiodides. In a facile, in-vitro synthesis we prepared the copper-pentaiodide complex [Cu(H(2)O)(6)(12-crown-4)(5)]I(6) · 2I(2), investigated its structure and antimicrobial properties. The chemical structure of the compound has been verified. We used agar well and disc-diffusion method assays against nine microbial reference strains in comparison to common antibiotics. The stable complex revealed excellent inhibition zones against C. albicans WDCM 00054, and strong antibacterial activities against several pathogens. [Cu(H(2)O)(6)(12-crown-4)(5)]I(6) · 2I(2) is a strong antimicrobial agent with an interesting crystal structure consisting of complexes located on an inversion center and surrounded by six 12-crown-4 molecules forming a cationic substructure. The six 12-crown-4 molecules form hydrogen bonds with the central Cu(H(2)O)(6). The anionic substructure is a halogen bonded polymer which is formed by formal I(5)(−) repetition units. The topology of this chain-type polyiodide is unique. The I(5)(−) repetition units can be understood as a triodide anion connected to two iodine molecules.