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High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain
Background: We evaluated whether, in subjects receiving haemodialysis (HD), the presence of diabetic foot syndrome (DFS) was associated with increased mortality compared with subjects with diabetes mellitus (DM) without DFS and with non-diabetic subjects. Methods: Retrospective, observational study...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037880/ https://www.ncbi.nlm.nih.gov/pubmed/33810545 http://dx.doi.org/10.3390/jcm10071368 |
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author | Dòria, Montserrat Betriu, Àngels Belart, Montserrat Rosado, Verónica Hernández, Marta Sarro, Felipe Real, Jordi Castelblanco, Esmeralda Pacheco, Linda Roxana Fernández, Elvira Franch-Nadal, Josep Gratacòs, Mònica Mauricio, Dídac |
author_facet | Dòria, Montserrat Betriu, Àngels Belart, Montserrat Rosado, Verónica Hernández, Marta Sarro, Felipe Real, Jordi Castelblanco, Esmeralda Pacheco, Linda Roxana Fernández, Elvira Franch-Nadal, Josep Gratacòs, Mònica Mauricio, Dídac |
author_sort | Dòria, Montserrat |
collection | PubMed |
description | Background: We evaluated whether, in subjects receiving haemodialysis (HD), the presence of diabetic foot syndrome (DFS) was associated with increased mortality compared with subjects with diabetes mellitus (DM) without DFS and with non-diabetic subjects. Methods: Retrospective, observational study in 220 subjects followed for six years. We calculated and compared the frequency and 5-year cumulative incidence of all-cause mortality, cardiovascular (CV) mortality, CV events, major adverse CV events (MACE), and new foot ulcer (FU) or amputation. We also examined prognostic factors of all-cause and CV mortality based on baseline characteristics. Results: DM patients had a 1.98 times higher probability of all-cause mortality than those without DM (p = 0.001) and 2.42 times higher likelihood of CV mortality and new FU or amputation (p = 0.002 and p = 0.008, respectively). In the DM cohort, only the risk of a new FU or amputation was 2.69 times higher among those with previous DFS (p = 0.021). In patients with DM, older age was the only predictor of all-cause and CV mortality (p = 0.001 and p = 0.014, respectively). Conclusions: Although all-cause and CV mortality were increased on HD subjects with DM, the presence of DFS did not modify the excess risk. Additional studies are warranted to further explore the impact of DFS in subjects with DM undergoing HD. |
format | Online Article Text |
id | pubmed-8037880 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80378802021-04-12 High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain Dòria, Montserrat Betriu, Àngels Belart, Montserrat Rosado, Verónica Hernández, Marta Sarro, Felipe Real, Jordi Castelblanco, Esmeralda Pacheco, Linda Roxana Fernández, Elvira Franch-Nadal, Josep Gratacòs, Mònica Mauricio, Dídac J Clin Med Article Background: We evaluated whether, in subjects receiving haemodialysis (HD), the presence of diabetic foot syndrome (DFS) was associated with increased mortality compared with subjects with diabetes mellitus (DM) without DFS and with non-diabetic subjects. Methods: Retrospective, observational study in 220 subjects followed for six years. We calculated and compared the frequency and 5-year cumulative incidence of all-cause mortality, cardiovascular (CV) mortality, CV events, major adverse CV events (MACE), and new foot ulcer (FU) or amputation. We also examined prognostic factors of all-cause and CV mortality based on baseline characteristics. Results: DM patients had a 1.98 times higher probability of all-cause mortality than those without DM (p = 0.001) and 2.42 times higher likelihood of CV mortality and new FU or amputation (p = 0.002 and p = 0.008, respectively). In the DM cohort, only the risk of a new FU or amputation was 2.69 times higher among those with previous DFS (p = 0.021). In patients with DM, older age was the only predictor of all-cause and CV mortality (p = 0.001 and p = 0.014, respectively). Conclusions: Although all-cause and CV mortality were increased on HD subjects with DM, the presence of DFS did not modify the excess risk. Additional studies are warranted to further explore the impact of DFS in subjects with DM undergoing HD. MDPI 2021-03-26 /pmc/articles/PMC8037880/ /pubmed/33810545 http://dx.doi.org/10.3390/jcm10071368 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Dòria, Montserrat Betriu, Àngels Belart, Montserrat Rosado, Verónica Hernández, Marta Sarro, Felipe Real, Jordi Castelblanco, Esmeralda Pacheco, Linda Roxana Fernández, Elvira Franch-Nadal, Josep Gratacòs, Mònica Mauricio, Dídac High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain |
title | High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain |
title_full | High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain |
title_fullStr | High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain |
title_full_unstemmed | High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain |
title_short | High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain |
title_sort | high incidence of adverse outcomes in haemodialysis patients with diabetes with or without diabetic foot syndrome: a 5-year observational study in lleida, spain |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037880/ https://www.ncbi.nlm.nih.gov/pubmed/33810545 http://dx.doi.org/10.3390/jcm10071368 |
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