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High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain

Background: We evaluated whether, in subjects receiving haemodialysis (HD), the presence of diabetic foot syndrome (DFS) was associated with increased mortality compared with subjects with diabetes mellitus (DM) without DFS and with non-diabetic subjects. Methods: Retrospective, observational study...

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Autores principales: Dòria, Montserrat, Betriu, Àngels, Belart, Montserrat, Rosado, Verónica, Hernández, Marta, Sarro, Felipe, Real, Jordi, Castelblanco, Esmeralda, Pacheco, Linda Roxana, Fernández, Elvira, Franch-Nadal, Josep, Gratacòs, Mònica, Mauricio, Dídac
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037880/
https://www.ncbi.nlm.nih.gov/pubmed/33810545
http://dx.doi.org/10.3390/jcm10071368
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author Dòria, Montserrat
Betriu, Àngels
Belart, Montserrat
Rosado, Verónica
Hernández, Marta
Sarro, Felipe
Real, Jordi
Castelblanco, Esmeralda
Pacheco, Linda Roxana
Fernández, Elvira
Franch-Nadal, Josep
Gratacòs, Mònica
Mauricio, Dídac
author_facet Dòria, Montserrat
Betriu, Àngels
Belart, Montserrat
Rosado, Verónica
Hernández, Marta
Sarro, Felipe
Real, Jordi
Castelblanco, Esmeralda
Pacheco, Linda Roxana
Fernández, Elvira
Franch-Nadal, Josep
Gratacòs, Mònica
Mauricio, Dídac
author_sort Dòria, Montserrat
collection PubMed
description Background: We evaluated whether, in subjects receiving haemodialysis (HD), the presence of diabetic foot syndrome (DFS) was associated with increased mortality compared with subjects with diabetes mellitus (DM) without DFS and with non-diabetic subjects. Methods: Retrospective, observational study in 220 subjects followed for six years. We calculated and compared the frequency and 5-year cumulative incidence of all-cause mortality, cardiovascular (CV) mortality, CV events, major adverse CV events (MACE), and new foot ulcer (FU) or amputation. We also examined prognostic factors of all-cause and CV mortality based on baseline characteristics. Results: DM patients had a 1.98 times higher probability of all-cause mortality than those without DM (p = 0.001) and 2.42 times higher likelihood of CV mortality and new FU or amputation (p = 0.002 and p = 0.008, respectively). In the DM cohort, only the risk of a new FU or amputation was 2.69 times higher among those with previous DFS (p = 0.021). In patients with DM, older age was the only predictor of all-cause and CV mortality (p = 0.001 and p = 0.014, respectively). Conclusions: Although all-cause and CV mortality were increased on HD subjects with DM, the presence of DFS did not modify the excess risk. Additional studies are warranted to further explore the impact of DFS in subjects with DM undergoing HD.
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spelling pubmed-80378802021-04-12 High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain Dòria, Montserrat Betriu, Àngels Belart, Montserrat Rosado, Verónica Hernández, Marta Sarro, Felipe Real, Jordi Castelblanco, Esmeralda Pacheco, Linda Roxana Fernández, Elvira Franch-Nadal, Josep Gratacòs, Mònica Mauricio, Dídac J Clin Med Article Background: We evaluated whether, in subjects receiving haemodialysis (HD), the presence of diabetic foot syndrome (DFS) was associated with increased mortality compared with subjects with diabetes mellitus (DM) without DFS and with non-diabetic subjects. Methods: Retrospective, observational study in 220 subjects followed for six years. We calculated and compared the frequency and 5-year cumulative incidence of all-cause mortality, cardiovascular (CV) mortality, CV events, major adverse CV events (MACE), and new foot ulcer (FU) or amputation. We also examined prognostic factors of all-cause and CV mortality based on baseline characteristics. Results: DM patients had a 1.98 times higher probability of all-cause mortality than those without DM (p = 0.001) and 2.42 times higher likelihood of CV mortality and new FU or amputation (p = 0.002 and p = 0.008, respectively). In the DM cohort, only the risk of a new FU or amputation was 2.69 times higher among those with previous DFS (p = 0.021). In patients with DM, older age was the only predictor of all-cause and CV mortality (p = 0.001 and p = 0.014, respectively). Conclusions: Although all-cause and CV mortality were increased on HD subjects with DM, the presence of DFS did not modify the excess risk. Additional studies are warranted to further explore the impact of DFS in subjects with DM undergoing HD. MDPI 2021-03-26 /pmc/articles/PMC8037880/ /pubmed/33810545 http://dx.doi.org/10.3390/jcm10071368 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Dòria, Montserrat
Betriu, Àngels
Belart, Montserrat
Rosado, Verónica
Hernández, Marta
Sarro, Felipe
Real, Jordi
Castelblanco, Esmeralda
Pacheco, Linda Roxana
Fernández, Elvira
Franch-Nadal, Josep
Gratacòs, Mònica
Mauricio, Dídac
High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain
title High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain
title_full High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain
title_fullStr High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain
title_full_unstemmed High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain
title_short High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain
title_sort high incidence of adverse outcomes in haemodialysis patients with diabetes with or without diabetic foot syndrome: a 5-year observational study in lleida, spain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037880/
https://www.ncbi.nlm.nih.gov/pubmed/33810545
http://dx.doi.org/10.3390/jcm10071368
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