Insights into the Role of the Microbiota and of Short-Chain Fatty Acids in Rubinstein–Taybi Syndrome

The short-chain fatty acid butyrate, produced by the gut microbiota, acts as a potent histone deacetylase (HDAC) inhibitor. We assessed possible ameliorative effects of butyrate, relative to other HDAC inhibitors, in in vitro and in vivo models of Rubinstein–Taybi syndrome (RSTS), a severe neurodeve...

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Detalles Bibliográficos
Autores principales: Di Fede, Elisabetta, Ottaviano, Emerenziana, Grazioli, Paolo, Ceccarani, Camilla, Galeone, Antonio, Parodi, Chiara, Colombo, Elisa Adele, Bassanini, Giulia, Fazio, Grazia, Severgnini, Marco, Milani, Donatella, Verduci, Elvira, Vaccari, Thomas, Massa, Valentina, Borghi, Elisa, Gervasini, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037970/
https://www.ncbi.nlm.nih.gov/pubmed/33807238
http://dx.doi.org/10.3390/ijms22073621

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