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Biodegradable and Biocompatible Silatrane Polymers

In this study, new biodegradable and biocompatible amphiphilic polymers were obtained by modifying the peripheral hydroxyl groups of branched polyethers and polyesters with organosilicon substituents. The structures of the synthesized polymers were confirmed by NMR and GPC. Organosilicon moieties of...

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Detalles Bibliográficos
Autores principales: Istratov, Vladislav V., Vasnev, Valerii A., Markova, Galy D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038000/
https://www.ncbi.nlm.nih.gov/pubmed/33810558
http://dx.doi.org/10.3390/molecules26071893
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author Istratov, Vladislav V.
Vasnev, Valerii A.
Markova, Galy D.
author_facet Istratov, Vladislav V.
Vasnev, Valerii A.
Markova, Galy D.
author_sort Istratov, Vladislav V.
collection PubMed
description In this study, new biodegradable and biocompatible amphiphilic polymers were obtained by modifying the peripheral hydroxyl groups of branched polyethers and polyesters with organosilicon substituents. The structures of the synthesized polymers were confirmed by NMR and GPC. Organosilicon moieties of the polymers were formed by silatranes and trimethylsilyl blocks and displayed hydrophilic and hydrophobic properties, respectively. The effect of the ratio of hydrophilic to hydrophobic organosilicon structures on the surface activity and biological activity of macromolecules was studied, together with the effect on these activities of the macromolecules’ molecular weight and chemical structure. In particular, the critical micelle concentrations were determined, the effect of the structure of the polymers on their wetting with aqueous solutions on glass and parafilm was described, and the aggregation stability of emulsions was studied. Finally, the effect of the polymer structures on their antifungal activity and seed germination stimulation was examined.
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spelling pubmed-80380002021-04-12 Biodegradable and Biocompatible Silatrane Polymers Istratov, Vladislav V. Vasnev, Valerii A. Markova, Galy D. Molecules Article In this study, new biodegradable and biocompatible amphiphilic polymers were obtained by modifying the peripheral hydroxyl groups of branched polyethers and polyesters with organosilicon substituents. The structures of the synthesized polymers were confirmed by NMR and GPC. Organosilicon moieties of the polymers were formed by silatranes and trimethylsilyl blocks and displayed hydrophilic and hydrophobic properties, respectively. The effect of the ratio of hydrophilic to hydrophobic organosilicon structures on the surface activity and biological activity of macromolecules was studied, together with the effect on these activities of the macromolecules’ molecular weight and chemical structure. In particular, the critical micelle concentrations were determined, the effect of the structure of the polymers on their wetting with aqueous solutions on glass and parafilm was described, and the aggregation stability of emulsions was studied. Finally, the effect of the polymer structures on their antifungal activity and seed germination stimulation was examined. MDPI 2021-03-26 /pmc/articles/PMC8038000/ /pubmed/33810558 http://dx.doi.org/10.3390/molecules26071893 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Istratov, Vladislav V.
Vasnev, Valerii A.
Markova, Galy D.
Biodegradable and Biocompatible Silatrane Polymers
title Biodegradable and Biocompatible Silatrane Polymers
title_full Biodegradable and Biocompatible Silatrane Polymers
title_fullStr Biodegradable and Biocompatible Silatrane Polymers
title_full_unstemmed Biodegradable and Biocompatible Silatrane Polymers
title_short Biodegradable and Biocompatible Silatrane Polymers
title_sort biodegradable and biocompatible silatrane polymers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038000/
https://www.ncbi.nlm.nih.gov/pubmed/33810558
http://dx.doi.org/10.3390/molecules26071893
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