Transposon Mutagenesis-Guided CRISPR/Cas9 Screening Strongly Implicates Dysregulation of Hippo/YAP Signaling in Malignant Peripheral Nerve Sheath Tumor Development

SIMPLE SUMMARY: Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive tumors with a complex genetic landscape. Patients with neurofibromatosis type 1 syndrome (NF1) are at a high risk of MPNSTs, which usually develop from pre-existing benign Schwann cell tumors called plexiform neu...

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Detalles Bibliográficos
Autores principales: Vélez-Reyes, Germán L., Koes, Nicholas, Ryu, Ji Hae, Kaufmann, Gabriel, Berner, Mariah, Weg, Madison T., Wolf, Natalie K., Rathe, Susan K., Ratner, Nancy, Moriarity, Branden S., Largaespada, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038069/
https://www.ncbi.nlm.nih.gov/pubmed/33808166
http://dx.doi.org/10.3390/cancers13071584

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