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Glycaemic Variability and Risk Factors of Pregnant Women with and without Gestational Diabetes Mellitus Measured by Continuous Glucose Monitoring

Background: The aim of the study was to compare the continuous glucose monitoring (CGM)-determined glycaemic variability (GV) of pregnant women with gestational diabetes mellitus (GDM) and without GDM (CG; control group). The secondary aim was to evaluate the association between risk factors of diab...

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Autores principales: Gáborová, Martina, Doničová, Viera, Bačová, Ivana, Pallayová, Mária, Bona, Martin, Peregrim, Igor, Grešová, Soňa, Štimmelová, Judita, Dzugasová, Barbora, Šalamonová Blichová, Lenka, Donič, Viliam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038105/
https://www.ncbi.nlm.nih.gov/pubmed/33806005
http://dx.doi.org/10.3390/ijerph18073402
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author Gáborová, Martina
Doničová, Viera
Bačová, Ivana
Pallayová, Mária
Bona, Martin
Peregrim, Igor
Grešová, Soňa
Štimmelová, Judita
Dzugasová, Barbora
Šalamonová Blichová, Lenka
Donič, Viliam
author_facet Gáborová, Martina
Doničová, Viera
Bačová, Ivana
Pallayová, Mária
Bona, Martin
Peregrim, Igor
Grešová, Soňa
Štimmelová, Judita
Dzugasová, Barbora
Šalamonová Blichová, Lenka
Donič, Viliam
author_sort Gáborová, Martina
collection PubMed
description Background: The aim of the study was to compare the continuous glucose monitoring (CGM)-determined glycaemic variability (GV) of pregnant women with gestational diabetes mellitus (GDM) and without GDM (CG; control group). The secondary aim was to evaluate the association between risk factors of diabetes in pregnancy and parameters of glyceamic control. Methods: Demographic, biometric and biochemical parameters were obtained for pregnant women (20–38 years old) who after an oral glucose tolerance test were examined by 7-day continuous glucose monitoring using a iPro(®)2 Professional CGM. Results: The differences in GV between women with GDM and CG compared by total area under glucose curve (total AUC, (mmol·day/L) was statistically significant (p = 0.006). Other parameters of glycaemic control such as mean glucose, standard deviation, coefficient of variation, J-index, % time-above target range 7.8 mmol/L (%TAR), % time-in range 3.5–7.8 mmol/L (%TIR), time-below target range 3.5 mmol/L (%TBR), glycated haemoglobin were not significantly different in the study groups. Risk factors (a family history of diabetes, pre-pregnancy BMI, higher weight gain and age) correlated with parameters of glycaemic control. Conclusions: We found a significant difference in GV of women with and without GDM by total AUC determined from CGM. TIR metrics were close to significance. Our work points at an increased GV in relation to the risk factors of GDM. Pregnant women with risk factors have higher probability of severe GV with its consequences on maternal and fetal health state.
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spelling pubmed-80381052021-04-12 Glycaemic Variability and Risk Factors of Pregnant Women with and without Gestational Diabetes Mellitus Measured by Continuous Glucose Monitoring Gáborová, Martina Doničová, Viera Bačová, Ivana Pallayová, Mária Bona, Martin Peregrim, Igor Grešová, Soňa Štimmelová, Judita Dzugasová, Barbora Šalamonová Blichová, Lenka Donič, Viliam Int J Environ Res Public Health Article Background: The aim of the study was to compare the continuous glucose monitoring (CGM)-determined glycaemic variability (GV) of pregnant women with gestational diabetes mellitus (GDM) and without GDM (CG; control group). The secondary aim was to evaluate the association between risk factors of diabetes in pregnancy and parameters of glyceamic control. Methods: Demographic, biometric and biochemical parameters were obtained for pregnant women (20–38 years old) who after an oral glucose tolerance test were examined by 7-day continuous glucose monitoring using a iPro(®)2 Professional CGM. Results: The differences in GV between women with GDM and CG compared by total area under glucose curve (total AUC, (mmol·day/L) was statistically significant (p = 0.006). Other parameters of glycaemic control such as mean glucose, standard deviation, coefficient of variation, J-index, % time-above target range 7.8 mmol/L (%TAR), % time-in range 3.5–7.8 mmol/L (%TIR), time-below target range 3.5 mmol/L (%TBR), glycated haemoglobin were not significantly different in the study groups. Risk factors (a family history of diabetes, pre-pregnancy BMI, higher weight gain and age) correlated with parameters of glycaemic control. Conclusions: We found a significant difference in GV of women with and without GDM by total AUC determined from CGM. TIR metrics were close to significance. Our work points at an increased GV in relation to the risk factors of GDM. Pregnant women with risk factors have higher probability of severe GV with its consequences on maternal and fetal health state. MDPI 2021-03-25 /pmc/articles/PMC8038105/ /pubmed/33806005 http://dx.doi.org/10.3390/ijerph18073402 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Gáborová, Martina
Doničová, Viera
Bačová, Ivana
Pallayová, Mária
Bona, Martin
Peregrim, Igor
Grešová, Soňa
Štimmelová, Judita
Dzugasová, Barbora
Šalamonová Blichová, Lenka
Donič, Viliam
Glycaemic Variability and Risk Factors of Pregnant Women with and without Gestational Diabetes Mellitus Measured by Continuous Glucose Monitoring
title Glycaemic Variability and Risk Factors of Pregnant Women with and without Gestational Diabetes Mellitus Measured by Continuous Glucose Monitoring
title_full Glycaemic Variability and Risk Factors of Pregnant Women with and without Gestational Diabetes Mellitus Measured by Continuous Glucose Monitoring
title_fullStr Glycaemic Variability and Risk Factors of Pregnant Women with and without Gestational Diabetes Mellitus Measured by Continuous Glucose Monitoring
title_full_unstemmed Glycaemic Variability and Risk Factors of Pregnant Women with and without Gestational Diabetes Mellitus Measured by Continuous Glucose Monitoring
title_short Glycaemic Variability and Risk Factors of Pregnant Women with and without Gestational Diabetes Mellitus Measured by Continuous Glucose Monitoring
title_sort glycaemic variability and risk factors of pregnant women with and without gestational diabetes mellitus measured by continuous glucose monitoring
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038105/
https://www.ncbi.nlm.nih.gov/pubmed/33806005
http://dx.doi.org/10.3390/ijerph18073402
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