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Hemoglobin A1c Levels Associated with Age and Gender in Taiwanese Adults without Prior Diagnosis with Diabetes

Several studies have reported that Hemoglobin A1c (HbA1c) levels increase with age for people without diabetes. However, HbA1c levels associated with age and gender have not been well investigated for Taiwanese adults. The objective of this study was to investigate the sex-specific association betwe...

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Autores principales: Huang, Shih-Hao, Huang, Peng-Ju, Li, Jhong-You, Su, Yu-De, Lu, Cheng-Chang, Shih, Chia-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038122/
https://www.ncbi.nlm.nih.gov/pubmed/33805890
http://dx.doi.org/10.3390/ijerph18073390
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author Huang, Shih-Hao
Huang, Peng-Ju
Li, Jhong-You
Su, Yu-De
Lu, Cheng-Chang
Shih, Chia-Lung
author_facet Huang, Shih-Hao
Huang, Peng-Ju
Li, Jhong-You
Su, Yu-De
Lu, Cheng-Chang
Shih, Chia-Lung
author_sort Huang, Shih-Hao
collection PubMed
description Several studies have reported that Hemoglobin A1c (HbA1c) levels increase with age for people without diabetes. However, HbA1c levels associated with age and gender have not been well investigated for Taiwanese adults. The objective of this study was to investigate the sex-specific association between HbA1c levels and age for Taiwanese adults without diabetes. The data were collected from the Taiwan Biobank database with inclusive criteria being participants without diabetes. The association between HbA1c values and age was conducted by linear regression analysis, HbA1c values between sexes were compared by two-sample t-test, and HbA1c levels among age groups were compared using one-way ANOVA. The results showed that HbA1c levels were positively correlated with age, and the levels for males were significantly higher than for females among all participants. However, there was no significantly positive correlation between HbA1c levels and age in males for age group of 50–70 years. The levels of males were significantly higher than females for age groups of 30–39 and 40–49 years. There were significant differences in HbA1c levels among age groups for all participants, males, and females except for the two age groups of 50–59 and 60–70 years in males. Age and gender were important factors affecting HbA1c levels. Our results suggested that the HbA1c cut-point levels for the diagnosis of diabetes should vary by age and gender.
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spelling pubmed-80381222021-04-12 Hemoglobin A1c Levels Associated with Age and Gender in Taiwanese Adults without Prior Diagnosis with Diabetes Huang, Shih-Hao Huang, Peng-Ju Li, Jhong-You Su, Yu-De Lu, Cheng-Chang Shih, Chia-Lung Int J Environ Res Public Health Article Several studies have reported that Hemoglobin A1c (HbA1c) levels increase with age for people without diabetes. However, HbA1c levels associated with age and gender have not been well investigated for Taiwanese adults. The objective of this study was to investigate the sex-specific association between HbA1c levels and age for Taiwanese adults without diabetes. The data were collected from the Taiwan Biobank database with inclusive criteria being participants without diabetes. The association between HbA1c values and age was conducted by linear regression analysis, HbA1c values between sexes were compared by two-sample t-test, and HbA1c levels among age groups were compared using one-way ANOVA. The results showed that HbA1c levels were positively correlated with age, and the levels for males were significantly higher than for females among all participants. However, there was no significantly positive correlation between HbA1c levels and age in males for age group of 50–70 years. The levels of males were significantly higher than females for age groups of 30–39 and 40–49 years. There were significant differences in HbA1c levels among age groups for all participants, males, and females except for the two age groups of 50–59 and 60–70 years in males. Age and gender were important factors affecting HbA1c levels. Our results suggested that the HbA1c cut-point levels for the diagnosis of diabetes should vary by age and gender. MDPI 2021-03-25 /pmc/articles/PMC8038122/ /pubmed/33805890 http://dx.doi.org/10.3390/ijerph18073390 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Huang, Shih-Hao
Huang, Peng-Ju
Li, Jhong-You
Su, Yu-De
Lu, Cheng-Chang
Shih, Chia-Lung
Hemoglobin A1c Levels Associated with Age and Gender in Taiwanese Adults without Prior Diagnosis with Diabetes
title Hemoglobin A1c Levels Associated with Age and Gender in Taiwanese Adults without Prior Diagnosis with Diabetes
title_full Hemoglobin A1c Levels Associated with Age and Gender in Taiwanese Adults without Prior Diagnosis with Diabetes
title_fullStr Hemoglobin A1c Levels Associated with Age and Gender in Taiwanese Adults without Prior Diagnosis with Diabetes
title_full_unstemmed Hemoglobin A1c Levels Associated with Age and Gender in Taiwanese Adults without Prior Diagnosis with Diabetes
title_short Hemoglobin A1c Levels Associated with Age and Gender in Taiwanese Adults without Prior Diagnosis with Diabetes
title_sort hemoglobin a1c levels associated with age and gender in taiwanese adults without prior diagnosis with diabetes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038122/
https://www.ncbi.nlm.nih.gov/pubmed/33805890
http://dx.doi.org/10.3390/ijerph18073390
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