A Novel LRRK2 Variant p.G2294R in the WD40 Domain Identified in Familial Parkinson’s Disease Affects LRRK2 Protein Levels

Leucine-rich repeat kinase 2 (LRRK2) is a major causative gene of late-onset familial Parkinson’s disease (PD). The suppression of kinase activity is believed to confer neuroprotection, as most pathogenic variants of LRRK2 associated with PD exhibit increased kinase activity. We herein report a nove...

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Detalles Bibliográficos
Autores principales: Ogata, Jun, Hirao, Kentaro, Nishioka, Kenya, Hayashida, Arisa, Li, Yuanzhe, Yoshino, Hiroyo, Shimizu, Soichiro, Hattori, Nobutaka, Imai, Yuzuru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038167/
https://www.ncbi.nlm.nih.gov/pubmed/33918221
http://dx.doi.org/10.3390/ijms22073708

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