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Insights into Terminal Sterilization Processes of Nanoparticles for Biomedical Applications
Nanoparticles possess a huge potential to be employed in numerous biomedical purposes; their applications may include drug delivery systems, gene therapy, and tissue engineering. However, the in vivo use in biomedical applications requires that nanoparticles exhibit sterility. Thus, diverse steriliz...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038324/ https://www.ncbi.nlm.nih.gov/pubmed/33916823 http://dx.doi.org/10.3390/molecules26072068 |
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author | Bernal-Chávez, Sergio A. Del Prado-Audelo, María Luisa Caballero-Florán, Isaac H. Giraldo-Gomez, David M. Figueroa-Gonzalez, Gabriela Reyes-Hernandez, Octavio D. González-Del Carmen, Manuel González-Torres, Maykel Cortés, Hernán Leyva-Gómez, Gerardo |
author_facet | Bernal-Chávez, Sergio A. Del Prado-Audelo, María Luisa Caballero-Florán, Isaac H. Giraldo-Gomez, David M. Figueroa-Gonzalez, Gabriela Reyes-Hernandez, Octavio D. González-Del Carmen, Manuel González-Torres, Maykel Cortés, Hernán Leyva-Gómez, Gerardo |
author_sort | Bernal-Chávez, Sergio A. |
collection | PubMed |
description | Nanoparticles possess a huge potential to be employed in numerous biomedical purposes; their applications may include drug delivery systems, gene therapy, and tissue engineering. However, the in vivo use in biomedical applications requires that nanoparticles exhibit sterility. Thus, diverse sterilization techniques have been developed to remove or destroy microbial contamination. The main sterilization methods include sterile filtration, autoclaving, ionizing radiation, and nonionizing radiation. Nonetheless, the sterilization processes can alter the stability, zeta potential, average particle size, and polydispersity index of diverse types of nanoparticles, depending on their composition. Thus, these methods may produce unwanted effects on the nanoparticles’ characteristics, affecting their safety and efficacy. Moreover, each sterilization method possesses advantages and drawbacks; thus, the suitable method’s choice depends on diverse factors such as the formulation’s characteristics, batch volume, available methods, and desired application. In this article, we describe the current sterilization methods of nanoparticles. Moreover, we discuss the advantages and drawbacks of these methods, pointing out the changes in nanoparticles’ biological and physicochemical characteristics after sterilization. Our main objective was to offer a comprehensive overview of terminal sterilization processes of nanoparticles for biomedical applications. |
format | Online Article Text |
id | pubmed-8038324 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80383242021-04-12 Insights into Terminal Sterilization Processes of Nanoparticles for Biomedical Applications Bernal-Chávez, Sergio A. Del Prado-Audelo, María Luisa Caballero-Florán, Isaac H. Giraldo-Gomez, David M. Figueroa-Gonzalez, Gabriela Reyes-Hernandez, Octavio D. González-Del Carmen, Manuel González-Torres, Maykel Cortés, Hernán Leyva-Gómez, Gerardo Molecules Review Nanoparticles possess a huge potential to be employed in numerous biomedical purposes; their applications may include drug delivery systems, gene therapy, and tissue engineering. However, the in vivo use in biomedical applications requires that nanoparticles exhibit sterility. Thus, diverse sterilization techniques have been developed to remove or destroy microbial contamination. The main sterilization methods include sterile filtration, autoclaving, ionizing radiation, and nonionizing radiation. Nonetheless, the sterilization processes can alter the stability, zeta potential, average particle size, and polydispersity index of diverse types of nanoparticles, depending on their composition. Thus, these methods may produce unwanted effects on the nanoparticles’ characteristics, affecting their safety and efficacy. Moreover, each sterilization method possesses advantages and drawbacks; thus, the suitable method’s choice depends on diverse factors such as the formulation’s characteristics, batch volume, available methods, and desired application. In this article, we describe the current sterilization methods of nanoparticles. Moreover, we discuss the advantages and drawbacks of these methods, pointing out the changes in nanoparticles’ biological and physicochemical characteristics after sterilization. Our main objective was to offer a comprehensive overview of terminal sterilization processes of nanoparticles for biomedical applications. MDPI 2021-04-03 /pmc/articles/PMC8038324/ /pubmed/33916823 http://dx.doi.org/10.3390/molecules26072068 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bernal-Chávez, Sergio A. Del Prado-Audelo, María Luisa Caballero-Florán, Isaac H. Giraldo-Gomez, David M. Figueroa-Gonzalez, Gabriela Reyes-Hernandez, Octavio D. González-Del Carmen, Manuel González-Torres, Maykel Cortés, Hernán Leyva-Gómez, Gerardo Insights into Terminal Sterilization Processes of Nanoparticles for Biomedical Applications |
title | Insights into Terminal Sterilization Processes of Nanoparticles for Biomedical Applications |
title_full | Insights into Terminal Sterilization Processes of Nanoparticles for Biomedical Applications |
title_fullStr | Insights into Terminal Sterilization Processes of Nanoparticles for Biomedical Applications |
title_full_unstemmed | Insights into Terminal Sterilization Processes of Nanoparticles for Biomedical Applications |
title_short | Insights into Terminal Sterilization Processes of Nanoparticles for Biomedical Applications |
title_sort | insights into terminal sterilization processes of nanoparticles for biomedical applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038324/ https://www.ncbi.nlm.nih.gov/pubmed/33916823 http://dx.doi.org/10.3390/molecules26072068 |
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