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Liposomes as Antibiotic Delivery Systems: A Promising Nanotechnological Strategy against Antimicrobial Resistance

Antimicrobial drugs are key tools to prevent and treat bacterial infections. Despite the early success of antibiotics, the current treatment of bacterial infections faces serious challenges due to the emergence and spread of resistant bacteria. Moreover, the decline of research and private investmen...

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Autores principales: Ferreira, Magda, Ogren, Maria, Dias, Joana N. R., Silva, Marta, Gil, Solange, Tavares, Luís, Aires-da-Silva, Frederico, Gaspar, Maria Manuela, Aguiar, Sandra Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038399/
https://www.ncbi.nlm.nih.gov/pubmed/33918529
http://dx.doi.org/10.3390/molecules26072047
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author Ferreira, Magda
Ogren, Maria
Dias, Joana N. R.
Silva, Marta
Gil, Solange
Tavares, Luís
Aires-da-Silva, Frederico
Gaspar, Maria Manuela
Aguiar, Sandra Isabel
author_facet Ferreira, Magda
Ogren, Maria
Dias, Joana N. R.
Silva, Marta
Gil, Solange
Tavares, Luís
Aires-da-Silva, Frederico
Gaspar, Maria Manuela
Aguiar, Sandra Isabel
author_sort Ferreira, Magda
collection PubMed
description Antimicrobial drugs are key tools to prevent and treat bacterial infections. Despite the early success of antibiotics, the current treatment of bacterial infections faces serious challenges due to the emergence and spread of resistant bacteria. Moreover, the decline of research and private investment in new antibiotics further aggravates this antibiotic crisis era. Overcoming the complexity of antimicrobial resistance must go beyond the search of new classes of antibiotics and include the development of alternative solutions. The evolution of nanomedicine has allowed the design of new drug delivery systems with improved therapeutic index for the incorporated compounds. One of the most promising strategies is their association to lipid-based delivery (nano)systems. A drug’s encapsulation in liposomes has been demonstrated to increase its accumulation at the infection site, minimizing drug toxicity and protecting the antibiotic from peripheral degradation. In addition, liposomes may be designed to fuse with bacterial cells, holding the potential to overcome antimicrobial resistance and biofilm formation and constituting a promising solution for the treatment of potential fatal multidrug-resistant bacterial infections, such as methicillin resistant Staphylococcus aureus. In this review, we aim to address the applicability of antibiotic encapsulated liposomes as an effective therapeutic strategy for bacterial infections.
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spelling pubmed-80383992021-04-12 Liposomes as Antibiotic Delivery Systems: A Promising Nanotechnological Strategy against Antimicrobial Resistance Ferreira, Magda Ogren, Maria Dias, Joana N. R. Silva, Marta Gil, Solange Tavares, Luís Aires-da-Silva, Frederico Gaspar, Maria Manuela Aguiar, Sandra Isabel Molecules Review Antimicrobial drugs are key tools to prevent and treat bacterial infections. Despite the early success of antibiotics, the current treatment of bacterial infections faces serious challenges due to the emergence and spread of resistant bacteria. Moreover, the decline of research and private investment in new antibiotics further aggravates this antibiotic crisis era. Overcoming the complexity of antimicrobial resistance must go beyond the search of new classes of antibiotics and include the development of alternative solutions. The evolution of nanomedicine has allowed the design of new drug delivery systems with improved therapeutic index for the incorporated compounds. One of the most promising strategies is their association to lipid-based delivery (nano)systems. A drug’s encapsulation in liposomes has been demonstrated to increase its accumulation at the infection site, minimizing drug toxicity and protecting the antibiotic from peripheral degradation. In addition, liposomes may be designed to fuse with bacterial cells, holding the potential to overcome antimicrobial resistance and biofilm formation and constituting a promising solution for the treatment of potential fatal multidrug-resistant bacterial infections, such as methicillin resistant Staphylococcus aureus. In this review, we aim to address the applicability of antibiotic encapsulated liposomes as an effective therapeutic strategy for bacterial infections. MDPI 2021-04-02 /pmc/articles/PMC8038399/ /pubmed/33918529 http://dx.doi.org/10.3390/molecules26072047 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ferreira, Magda
Ogren, Maria
Dias, Joana N. R.
Silva, Marta
Gil, Solange
Tavares, Luís
Aires-da-Silva, Frederico
Gaspar, Maria Manuela
Aguiar, Sandra Isabel
Liposomes as Antibiotic Delivery Systems: A Promising Nanotechnological Strategy against Antimicrobial Resistance
title Liposomes as Antibiotic Delivery Systems: A Promising Nanotechnological Strategy against Antimicrobial Resistance
title_full Liposomes as Antibiotic Delivery Systems: A Promising Nanotechnological Strategy against Antimicrobial Resistance
title_fullStr Liposomes as Antibiotic Delivery Systems: A Promising Nanotechnological Strategy against Antimicrobial Resistance
title_full_unstemmed Liposomes as Antibiotic Delivery Systems: A Promising Nanotechnological Strategy against Antimicrobial Resistance
title_short Liposomes as Antibiotic Delivery Systems: A Promising Nanotechnological Strategy against Antimicrobial Resistance
title_sort liposomes as antibiotic delivery systems: a promising nanotechnological strategy against antimicrobial resistance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038399/
https://www.ncbi.nlm.nih.gov/pubmed/33918529
http://dx.doi.org/10.3390/molecules26072047
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