Indolizines and Their Hetero/Benzo Derivatives in Reactions of [8+2] Cycloaddition

Peculiarities of [8+2] cycloaddition of acetylenes to indolizines are reviewed. Especially mentioned are indolizines with leaving groups at positions 3 and 5. Cycloaddition to aza- and benzo derivatives are reviewed, as well as 1,10-cyclizations and processes leading to cyclazines where indolizines...

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Autores principales: Babaev, Eugene V., Shadrin, Ivan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038407/
https://www.ncbi.nlm.nih.gov/pubmed/33916655
http://dx.doi.org/10.3390/molecules26072050
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author Babaev, Eugene V.
Shadrin, Ivan A.
author_facet Babaev, Eugene V.
Shadrin, Ivan A.
author_sort Babaev, Eugene V.
collection PubMed
description Peculiarities of [8+2] cycloaddition of acetylenes to indolizines are reviewed. Especially mentioned are indolizines with leaving groups at positions 3 and 5. Cycloaddition to aza- and benzo derivatives are reviewed, as well as 1,10-cyclizations and processes leading to cyclazines where indolizines are intermediates. Mechanistic features (adducts and cycloadducts) and theoretical aspects (one- or two-steps mechanism) are reviewed.
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spelling pubmed-80384072021-04-12 Indolizines and Their Hetero/Benzo Derivatives in Reactions of [8+2] Cycloaddition Babaev, Eugene V. Shadrin, Ivan A. Molecules Review Peculiarities of [8+2] cycloaddition of acetylenes to indolizines are reviewed. Especially mentioned are indolizines with leaving groups at positions 3 and 5. Cycloaddition to aza- and benzo derivatives are reviewed, as well as 1,10-cyclizations and processes leading to cyclazines where indolizines are intermediates. Mechanistic features (adducts and cycloadducts) and theoretical aspects (one- or two-steps mechanism) are reviewed. MDPI 2021-04-03 /pmc/articles/PMC8038407/ /pubmed/33916655 http://dx.doi.org/10.3390/molecules26072050 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Babaev, Eugene V.
Shadrin, Ivan A.
Indolizines and Their Hetero/Benzo Derivatives in Reactions of [8+2] Cycloaddition
title Indolizines and Their Hetero/Benzo Derivatives in Reactions of [8+2] Cycloaddition
title_full Indolizines and Their Hetero/Benzo Derivatives in Reactions of [8+2] Cycloaddition
title_fullStr Indolizines and Their Hetero/Benzo Derivatives in Reactions of [8+2] Cycloaddition
title_full_unstemmed Indolizines and Their Hetero/Benzo Derivatives in Reactions of [8+2] Cycloaddition
title_short Indolizines and Their Hetero/Benzo Derivatives in Reactions of [8+2] Cycloaddition
title_sort indolizines and their hetero/benzo derivatives in reactions of [8+2] cycloaddition
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038407/
https://www.ncbi.nlm.nih.gov/pubmed/33916655
http://dx.doi.org/10.3390/molecules26072050
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