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Effect of D-Mannitol on the Microstructure and Rheology of Non-Aqueous Carbopol Microgels

D-mannitol is a common polyol that is used as additive in pharmaceutical and personal care product formulations. We investigated its effect on the microstructure and rheology of novel non-aqueous Carbopol dispersions employing traditional and time-resolved rheological analysis. We considered two typ...

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Detalles Bibliográficos
Autores principales: Migliozzi, Simona, Angeli, Panagiota, Mazzei, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038445/
https://www.ncbi.nlm.nih.gov/pubmed/33916550
http://dx.doi.org/10.3390/ma14071782
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author Migliozzi, Simona
Angeli, Panagiota
Mazzei, Luca
author_facet Migliozzi, Simona
Angeli, Panagiota
Mazzei, Luca
author_sort Migliozzi, Simona
collection PubMed
description D-mannitol is a common polyol that is used as additive in pharmaceutical and personal care product formulations. We investigated its effect on the microstructure and rheology of novel non-aqueous Carbopol dispersions employing traditional and time-resolved rheological analysis. We considered two types of sample, (i) fresh (i.e., mannitol completely dissolved in solution) and aged (i.e., visible in crystalline form). The analysis of the intracycle rheological transitions that were observed for different samples revealed that, when completely dissolved in solution, mannitol does not alter the rheological behaviour of the Carbopol dispersions. This highlights that the chemical similarity of the additive with the molecules of the surrounding solvent allows preserving the swollen dimension and interparticle interactions of the Carbopol molecules. Conversely, when crystals are present, a hierarchical structure forms, consisting of a small dispersed phase (Carbopol) agglomerated around a big dispersed phase (crystals). In keeping with this microstructural picture, as the concentration of Carbopol reduces, the local dynamics of the crystals gradually start to control the integrity of the microstructure. Rheologically, this results in a higher elasticity of the suspensions at infinitesimal deformations, but a fragile yielding process at intermediate strains.
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spelling pubmed-80384452021-04-12 Effect of D-Mannitol on the Microstructure and Rheology of Non-Aqueous Carbopol Microgels Migliozzi, Simona Angeli, Panagiota Mazzei, Luca Materials (Basel) Article D-mannitol is a common polyol that is used as additive in pharmaceutical and personal care product formulations. We investigated its effect on the microstructure and rheology of novel non-aqueous Carbopol dispersions employing traditional and time-resolved rheological analysis. We considered two types of sample, (i) fresh (i.e., mannitol completely dissolved in solution) and aged (i.e., visible in crystalline form). The analysis of the intracycle rheological transitions that were observed for different samples revealed that, when completely dissolved in solution, mannitol does not alter the rheological behaviour of the Carbopol dispersions. This highlights that the chemical similarity of the additive with the molecules of the surrounding solvent allows preserving the swollen dimension and interparticle interactions of the Carbopol molecules. Conversely, when crystals are present, a hierarchical structure forms, consisting of a small dispersed phase (Carbopol) agglomerated around a big dispersed phase (crystals). In keeping with this microstructural picture, as the concentration of Carbopol reduces, the local dynamics of the crystals gradually start to control the integrity of the microstructure. Rheologically, this results in a higher elasticity of the suspensions at infinitesimal deformations, but a fragile yielding process at intermediate strains. MDPI 2021-04-04 /pmc/articles/PMC8038445/ /pubmed/33916550 http://dx.doi.org/10.3390/ma14071782 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Migliozzi, Simona
Angeli, Panagiota
Mazzei, Luca
Effect of D-Mannitol on the Microstructure and Rheology of Non-Aqueous Carbopol Microgels
title Effect of D-Mannitol on the Microstructure and Rheology of Non-Aqueous Carbopol Microgels
title_full Effect of D-Mannitol on the Microstructure and Rheology of Non-Aqueous Carbopol Microgels
title_fullStr Effect of D-Mannitol on the Microstructure and Rheology of Non-Aqueous Carbopol Microgels
title_full_unstemmed Effect of D-Mannitol on the Microstructure and Rheology of Non-Aqueous Carbopol Microgels
title_short Effect of D-Mannitol on the Microstructure and Rheology of Non-Aqueous Carbopol Microgels
title_sort effect of d-mannitol on the microstructure and rheology of non-aqueous carbopol microgels
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038445/
https://www.ncbi.nlm.nih.gov/pubmed/33916550
http://dx.doi.org/10.3390/ma14071782
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