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Effect of D-Mannitol on the Microstructure and Rheology of Non-Aqueous Carbopol Microgels
D-mannitol is a common polyol that is used as additive in pharmaceutical and personal care product formulations. We investigated its effect on the microstructure and rheology of novel non-aqueous Carbopol dispersions employing traditional and time-resolved rheological analysis. We considered two typ...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038445/ https://www.ncbi.nlm.nih.gov/pubmed/33916550 http://dx.doi.org/10.3390/ma14071782 |
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author | Migliozzi, Simona Angeli, Panagiota Mazzei, Luca |
author_facet | Migliozzi, Simona Angeli, Panagiota Mazzei, Luca |
author_sort | Migliozzi, Simona |
collection | PubMed |
description | D-mannitol is a common polyol that is used as additive in pharmaceutical and personal care product formulations. We investigated its effect on the microstructure and rheology of novel non-aqueous Carbopol dispersions employing traditional and time-resolved rheological analysis. We considered two types of sample, (i) fresh (i.e., mannitol completely dissolved in solution) and aged (i.e., visible in crystalline form). The analysis of the intracycle rheological transitions that were observed for different samples revealed that, when completely dissolved in solution, mannitol does not alter the rheological behaviour of the Carbopol dispersions. This highlights that the chemical similarity of the additive with the molecules of the surrounding solvent allows preserving the swollen dimension and interparticle interactions of the Carbopol molecules. Conversely, when crystals are present, a hierarchical structure forms, consisting of a small dispersed phase (Carbopol) agglomerated around a big dispersed phase (crystals). In keeping with this microstructural picture, as the concentration of Carbopol reduces, the local dynamics of the crystals gradually start to control the integrity of the microstructure. Rheologically, this results in a higher elasticity of the suspensions at infinitesimal deformations, but a fragile yielding process at intermediate strains. |
format | Online Article Text |
id | pubmed-8038445 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80384452021-04-12 Effect of D-Mannitol on the Microstructure and Rheology of Non-Aqueous Carbopol Microgels Migliozzi, Simona Angeli, Panagiota Mazzei, Luca Materials (Basel) Article D-mannitol is a common polyol that is used as additive in pharmaceutical and personal care product formulations. We investigated its effect on the microstructure and rheology of novel non-aqueous Carbopol dispersions employing traditional and time-resolved rheological analysis. We considered two types of sample, (i) fresh (i.e., mannitol completely dissolved in solution) and aged (i.e., visible in crystalline form). The analysis of the intracycle rheological transitions that were observed for different samples revealed that, when completely dissolved in solution, mannitol does not alter the rheological behaviour of the Carbopol dispersions. This highlights that the chemical similarity of the additive with the molecules of the surrounding solvent allows preserving the swollen dimension and interparticle interactions of the Carbopol molecules. Conversely, when crystals are present, a hierarchical structure forms, consisting of a small dispersed phase (Carbopol) agglomerated around a big dispersed phase (crystals). In keeping with this microstructural picture, as the concentration of Carbopol reduces, the local dynamics of the crystals gradually start to control the integrity of the microstructure. Rheologically, this results in a higher elasticity of the suspensions at infinitesimal deformations, but a fragile yielding process at intermediate strains. MDPI 2021-04-04 /pmc/articles/PMC8038445/ /pubmed/33916550 http://dx.doi.org/10.3390/ma14071782 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Migliozzi, Simona Angeli, Panagiota Mazzei, Luca Effect of D-Mannitol on the Microstructure and Rheology of Non-Aqueous Carbopol Microgels |
title | Effect of D-Mannitol on the Microstructure and Rheology of Non-Aqueous Carbopol Microgels |
title_full | Effect of D-Mannitol on the Microstructure and Rheology of Non-Aqueous Carbopol Microgels |
title_fullStr | Effect of D-Mannitol on the Microstructure and Rheology of Non-Aqueous Carbopol Microgels |
title_full_unstemmed | Effect of D-Mannitol on the Microstructure and Rheology of Non-Aqueous Carbopol Microgels |
title_short | Effect of D-Mannitol on the Microstructure and Rheology of Non-Aqueous Carbopol Microgels |
title_sort | effect of d-mannitol on the microstructure and rheology of non-aqueous carbopol microgels |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038445/ https://www.ncbi.nlm.nih.gov/pubmed/33916550 http://dx.doi.org/10.3390/ma14071782 |
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