High-Fat Diet Leads to Reduced Protein O-GlcNAcylation and Mitochondrial Defects Promoting the Development of Alzheimer’s Disease Signatures

The disturbance of protein O-GlcNAcylation is emerging as a possible link between altered brain metabolism and the progression of neurodegeneration. As observed in brains with Alzheimer’s disease (AD), flaws of the cerebral glucose uptake translate into reduced protein O-GlcNAcylation, which promote...

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Detalles Bibliográficos
Autores principales: Zuliani, Ilaria, Lanzillotta, Chiara, Tramutola, Antonella, Barone, Eugenio, Perluigi, Marzia, Rinaldo, Serena, Paone, Alessio, Cutruzzolà, Francesca, Bellanti, Francesco, Spinelli, Matteo, Natale, Francesca, Fusco, Salvatore, Grassi, Claudio, Di Domenico, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038495/
https://www.ncbi.nlm.nih.gov/pubmed/33916835
http://dx.doi.org/10.3390/ijms22073746

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