Genome engineering technologies in rabbits

The rabbit has been recognized as a valuable model in various biomedical and biological research fields because of its intermediate size and phylogenetic proximity to primates. However, the technology for precise genome manipulations in rabbit has been stalled for decades, severely limiting its appl...

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Detalles Bibliográficos
Autores principales: Song, Jun, Zhang, Jifeng, Xu, Jie, Garcia-Barrio, Minerva, Chen, Y. Eugene, Yang, Dongshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Department of Journal of Biomedical Research 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038526/
https://www.ncbi.nlm.nih.gov/pubmed/32934190
http://dx.doi.org/10.7555/JBR.34.20190133
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author Song, Jun
Zhang, Jifeng
Xu, Jie
Garcia-Barrio, Minerva
Chen, Y. Eugene
Yang, Dongshan
author_facet Song, Jun
Zhang, Jifeng
Xu, Jie
Garcia-Barrio, Minerva
Chen, Y. Eugene
Yang, Dongshan
author_sort Song, Jun
collection PubMed
description The rabbit has been recognized as a valuable model in various biomedical and biological research fields because of its intermediate size and phylogenetic proximity to primates. However, the technology for precise genome manipulations in rabbit has been stalled for decades, severely limiting its applications in biomedical research. Novel genome editing technologies, especially CRISPR/Cas9, have remarkably enhanced precise genome manipulation in rabbits, and shown their superiority and promise for generating rabbit models of human genetic diseases. In this review, we summarize the brief history of transgenic rabbit technology and the development of novel genome editing technologies in rabbits.
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spelling pubmed-80385262021-04-16 Genome engineering technologies in rabbits Song, Jun Zhang, Jifeng Xu, Jie Garcia-Barrio, Minerva Chen, Y. Eugene Yang, Dongshan J Biomed Res Review Article The rabbit has been recognized as a valuable model in various biomedical and biological research fields because of its intermediate size and phylogenetic proximity to primates. However, the technology for precise genome manipulations in rabbit has been stalled for decades, severely limiting its applications in biomedical research. Novel genome editing technologies, especially CRISPR/Cas9, have remarkably enhanced precise genome manipulation in rabbits, and shown their superiority and promise for generating rabbit models of human genetic diseases. In this review, we summarize the brief history of transgenic rabbit technology and the development of novel genome editing technologies in rabbits. Editorial Department of Journal of Biomedical Research 2021-03 2020-06-12 /pmc/articles/PMC8038526/ /pubmed/32934190 http://dx.doi.org/10.7555/JBR.34.20190133 Text en Copyright and License information: Journal of Biomedical Research, CAS Springer-Verlag Berlin Heidelberg 2021 https://creativecommons.org/licenses/by-nc-sa/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/)
spellingShingle Review Article
Song, Jun
Zhang, Jifeng
Xu, Jie
Garcia-Barrio, Minerva
Chen, Y. Eugene
Yang, Dongshan
Genome engineering technologies in rabbits
title Genome engineering technologies in rabbits
title_full Genome engineering technologies in rabbits
title_fullStr Genome engineering technologies in rabbits
title_full_unstemmed Genome engineering technologies in rabbits
title_short Genome engineering technologies in rabbits
title_sort genome engineering technologies in rabbits
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038526/
https://www.ncbi.nlm.nih.gov/pubmed/32934190
http://dx.doi.org/10.7555/JBR.34.20190133
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