Cargando…

Synthesis, Characterization and Biological Evaluation of New 3,5-Disubstituted-Pyrazoline Derivatives as Potential Anti-Mycobacterium tuberculosis H37Ra Compounds

A total of fourteen pyrazoline derivatives were synthesized through cyclo-condensation reactions by chalcone derivatives with different types of semicarbazide. These compounds were characterized by IR, 1D-NMR ((1)H, (13)C and Distortionless Enhancement by Polarization Transfer - DEPT-135) and 2D-NMR...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wong, Kok Tong, Osman, Hasnah, Parumasivam, Thaigarajan, Supratman, Unang, Che Omar, Mohammad Tasyriq, Azmi, Mohamad Nurul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038544/ https://www.ncbi.nlm.nih.gov/pubmed/33916423 http://dx.doi.org/10.3390/molecules26072081

Ejemplares similares

Antituberculosis activity, phytochemical identification of Costus speciosus (J. Koenig) Sm., Cymbopogon citratus (DC. Ex Nees) Stapf., and Tabernaemontana coronaria (L.) Willd. and their effects on the growth kinetics and cellular integrity of Mycobacterium tuberculosis H37Rv
por: Mohamad, Suriyati, et al.
Publicado: (2018)

Comparison of membrane proteins of Mycobacterium tuberculosis H37Rv and H37Ra strains
por: Målen, Hiwa, et al.
Publicado: (2011)

4-Thiazolidinone coumarin derivatives as two-component NS2B/NS3 DENV flavivirus serine protease inhibitors: synthesis, molecular docking, biological evaluation and structure–activity relationship studies
por: Yusufzai, Samina Khan, et al.
Publicado: (2018)

Andrographis paniculata Dosage Forms and Advances in Nanoparticulate Delivery Systems: An Overview
por: Raman, Subashini, et al.
Publicado: (2022)

Eurycoma longifolia: an overview on the pharmacological properties for the treatment of common cancer
por: Jothi, Shankar, et al.
Publicado: (2023)

Resin Glycosides from Convolvulaceae Family: An Update
por: Maharani, Rani, et al.
Publicado: (2022)

The Cytotoxic Activity of Dammarane-Type Triterpenoids Isolated from the Stem Bark of Aglaia cucullata (Meliaceae)
por: Purnama, et al.
Publicado: (2023)

Microwave-Assisted Synthesis of Some 3,5-Arylated 2-Pyrazolines
por: Azarifar, Davood, et al.
Publicado: (2003)

Microarray analysis of the in vitro granulomatous response to Mycobacterium tuberculosis H37Ra
por: Reyes, Niradiz, et al.
Publicado: (2015)

Antimycobacterial Activity of Cinnamaldehyde in a Mycobacterium tuberculosis(H37Ra) Model
por: Sawicki, Rafal, et al.
Publicado: (2018)

Crystal structures of 3,5-bis[(E)-3-hydroxybenzylidene]-1-methylpiperidin-4-one and 3,5-bis[(E)-2-chlorobenzylidene]-1-methylpiperidin-4-one
por: Eryanti, Yum, et al.
Publicado: (2015)

Substituent Effects on the N–H Bond Dissociation Enthalpies, Ionization Energies, Acidities, and Radical Scavenging Behavior of 3,7-Disubstituted Phenoxazines and 3,7-Disubstituted Phenothiazines
por: Thao, Pham Thi Thu, et al.
Publicado: (2020)

Mycobacterium tuberculosis H37Ra: a surrogate for the expression of conserved, multimeric proteins of M.tb H37Rv
por: Boradia, Vishant Mahendra, et al.
Publicado: (2016)

Integrated Multi-Omic Analysis of Mycobacterium tuberculosis H37Ra Redefines Virulence Attributes
por: Pinto, Sneha M., et al.
Publicado: (2018)

Comparative transcriptomic analysis of THP‐1‐derived macrophages infected with Mycobacterium tuberculosis H37Rv, H37Ra and BCG
por: Pu, Wenyuan, et al.
Publicado: (2021)

Synthesis and Characterization of New 3,5-Dinaphthyl Substituted 2-Pyrazolines and Study of Their Antimicrobial Activity
por: Azarifar, Davood, et al.
Publicado: (2002)

Biomedical Applications of Polyhydroxyalkanoate in Tissue Engineering
por: Pulingam, Thiruchelvi, et al.
Publicado: (2022)

Genetic Basis of Virulence Attenuation Revealed by Comparative Genomic Analysis of Mycobacterium tuberculosis Strain H37Ra versus H37Rv
por: Zheng, Huajun, et al.
Publicado: (2008)

Simple two-step synthesis of 2,4-disubstituted pyrroles and 3,5-disubstituted pyrrole-2-carbonitriles from enones
por: Kucukdisli, Murat, et al.
Publicado: (2014)

Tyrosol Derivatives, Bearing 3,5-Disubstituted Isoxazole and 1,4-Disubstituted Triazole, as Potential Antileukemia Agents by Promoting Apoptosis
por: Abdelkafi-Koubaa, Zaineb, et al.
Publicado: (2022)

Kallolide A acetate pyrazoline
por: Rodríguez-Escudero, Idaliz, et al.
Publicado: (2011)

PLGA particulate subunit tuberculosis vaccines promote humoral and Th17 responses but do not enhance control of Mycobacterium tuberculosis infection
por: Ashhurst, Anneliese S., et al.
Publicado: (2018)

The Mycobacterium tuberculosis H37Ra gene MRA_1916 causes growth defects upon down-regulation
por: Singh, Kumar Sachin, et al.
Publicado: (2015)

MRA_1571 is required for isoleucine biosynthesis and improves Mycobacterium tuberculosis H37Ra survival under stress
por: Sharma, Rishabh, et al.
Publicado: (2016)

Dammarane-Type Triterpenoid from the Stem Bark of Aglaia elliptica (Meliaceae) and Its Cytotoxic Activities
por: Farabi, Kindi, et al.
Publicado: (2022)

Retraction Note: Expression of Functional Anti-p24 scFv 183-H12-5C in HEK293T and Jurkat T Cells
por: Omar, Mohammad Tasyriq Che
Publicado: (2018)

Expression of Functional Anti-p24 scFv 183-H12-5C in HEK293T and Jurkat T Cells
por: Che Omar, Mohammad Tasyriq
Publicado: (2017)

Data analysis of molecular dynamics simulation trajectories of β-sitosterol, sonidegib and cholesterol in smoothened protein with the CHARMM36 force field
por: Che Omar, Mohammad Tasyriq
Publicado: (2020)

Phytochemistry and Biological Activities of Endophytic Fungi from the Meliaceae Family
por: Mulyani, Yeni, et al.
Publicado: (2023)

Identification of moaA3 gene in patient isolates of Mycobacterium tuberculosis in Kerala, which is absent in M. tuberculosis H37Rv and H37Ra
por: Sarojini, Suma, et al.
Publicado: (2005)

The Transcriptional Foundations of Sp110-mediated Macrophage (RAW264.7) Resistance to Mycobacterium tuberculosis H37Ra
por: Wu, Yongyan, et al.
Publicado: (2016)

Sesquiterpenoids from Meliaceae Family and Their Biological Activities
por: Riyadi, Sandra Amalia, et al.
Publicado: (2023)

Pyrazoles and Pyrazolines as Anti-Inflammatory Agents
por: Mantzanidou, Martha, et al.
Publicado: (2021)

Advances in Polyhydroxyalkanoate Nanocarriers for Effective Drug Delivery: An Overview and Challenges
por: Prakash, Priyanka, et al.
Publicado: (2022)

5-Hydroxy-1-(3-hydroxy-2-naphthoyl)-3,5-dimethyl-2-pyrazoline
por: Chen, Yuting, et al.
Publicado: (2008)

Crystal Structure of Fad35R from Mycobacterium tuberculosis H37Rv in the Apo-State
por: Singh, Appu Kumar, et al.
Publicado: (2015)

Sinomenine Suppresses Osteoclast Formation and Mycobacterium tuberculosis H37Ra-Induced Bone Loss by Modulating RANKL Signaling Pathways
por: Li, Xiaojuan, et al.
Publicado: (2013)

CLEC9A modulates macrophage-mediated neutrophil recruitment in response to heat-killed Mycobacterium tuberculosis H37Ra
por: Cheng, An-Chieh, et al.
Publicado: (2017)

Cyclic-di-AMP Phosphodiesterase Elicits Protective Immune Responses Against Mycobacterium tuberculosis H37Ra Infection in Mice
por: Lu, Yanzhi, et al.
Publicado: (2022)

Herp regulates intracellular survival of Mycobacterium tuberculosis H37Ra in macrophages by regulating reactive oxygen species-mediated autophagy
por: Son, Sang-Hun, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ta2tiub7a4rlls9mm2m52j9q33