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Kidney Injury Caused by Preeclamptic Pregnancy Recovers Postpartum in a Transgenic Rat Model

Preeclampsia (PE) is characterized by the onset of hypertension (≥140/90 mmHg) and presence of proteinuria (>300 mg/L/24 h urine) or other maternal organ dysfunctions. During human PE, renal injuries have been observed. Some studies suggest that women with PE diagnosis have an increased risk to d...

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Autores principales: Kedziora, Sarah M., Kräker, Kristin, Markó, Lajos, Binder, Julia, Sugulle, Meryam, Gauster, Martin, Müller, Dominik N., Dechend, Ralf, Haase, Nadine, Herse, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038582/
https://www.ncbi.nlm.nih.gov/pubmed/33916404
http://dx.doi.org/10.3390/ijms22073762
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author Kedziora, Sarah M.
Kräker, Kristin
Markó, Lajos
Binder, Julia
Sugulle, Meryam
Gauster, Martin
Müller, Dominik N.
Dechend, Ralf
Haase, Nadine
Herse, Florian
author_facet Kedziora, Sarah M.
Kräker, Kristin
Markó, Lajos
Binder, Julia
Sugulle, Meryam
Gauster, Martin
Müller, Dominik N.
Dechend, Ralf
Haase, Nadine
Herse, Florian
author_sort Kedziora, Sarah M.
collection PubMed
description Preeclampsia (PE) is characterized by the onset of hypertension (≥140/90 mmHg) and presence of proteinuria (>300 mg/L/24 h urine) or other maternal organ dysfunctions. During human PE, renal injuries have been observed. Some studies suggest that women with PE diagnosis have an increased risk to develop renal diseases later in life. However, in human studies PE as a single cause of this development cannot be investigated. Here, we aimed to investigate the effect of PE on postpartum renal damage in an established transgenic PE rat model. Female rats harboring the human-angiotensinogen gene develop a preeclamptic phenotype after mating with male rats harboring the human-renin gene, but are normotensive before and after pregnancy. During pregnancy PE rats developed mild tubular and glomerular changes assessed by histologic analysis, increased gene expression of renal damage markers such as kidney injury marker 1 and connective-tissue growth factor, and albuminuria compared to female wild-type rats (WT). However, four weeks postpartum, most PE-related renal pathologies were absent, including albuminuria and elevated biomarker expression. Only mild enlargement of the glomerular tuft could be detected. Overall, the glomerular and tubular function were affected during pregnancy in the transgenic PE rat. However, almost all these pathologies observed during PE recovered postpartum.
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spelling pubmed-80385822021-04-12 Kidney Injury Caused by Preeclamptic Pregnancy Recovers Postpartum in a Transgenic Rat Model Kedziora, Sarah M. Kräker, Kristin Markó, Lajos Binder, Julia Sugulle, Meryam Gauster, Martin Müller, Dominik N. Dechend, Ralf Haase, Nadine Herse, Florian Int J Mol Sci Article Preeclampsia (PE) is characterized by the onset of hypertension (≥140/90 mmHg) and presence of proteinuria (>300 mg/L/24 h urine) or other maternal organ dysfunctions. During human PE, renal injuries have been observed. Some studies suggest that women with PE diagnosis have an increased risk to develop renal diseases later in life. However, in human studies PE as a single cause of this development cannot be investigated. Here, we aimed to investigate the effect of PE on postpartum renal damage in an established transgenic PE rat model. Female rats harboring the human-angiotensinogen gene develop a preeclamptic phenotype after mating with male rats harboring the human-renin gene, but are normotensive before and after pregnancy. During pregnancy PE rats developed mild tubular and glomerular changes assessed by histologic analysis, increased gene expression of renal damage markers such as kidney injury marker 1 and connective-tissue growth factor, and albuminuria compared to female wild-type rats (WT). However, four weeks postpartum, most PE-related renal pathologies were absent, including albuminuria and elevated biomarker expression. Only mild enlargement of the glomerular tuft could be detected. Overall, the glomerular and tubular function were affected during pregnancy in the transgenic PE rat. However, almost all these pathologies observed during PE recovered postpartum. MDPI 2021-04-05 /pmc/articles/PMC8038582/ /pubmed/33916404 http://dx.doi.org/10.3390/ijms22073762 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kedziora, Sarah M.
Kräker, Kristin
Markó, Lajos
Binder, Julia
Sugulle, Meryam
Gauster, Martin
Müller, Dominik N.
Dechend, Ralf
Haase, Nadine
Herse, Florian
Kidney Injury Caused by Preeclamptic Pregnancy Recovers Postpartum in a Transgenic Rat Model
title Kidney Injury Caused by Preeclamptic Pregnancy Recovers Postpartum in a Transgenic Rat Model
title_full Kidney Injury Caused by Preeclamptic Pregnancy Recovers Postpartum in a Transgenic Rat Model
title_fullStr Kidney Injury Caused by Preeclamptic Pregnancy Recovers Postpartum in a Transgenic Rat Model
title_full_unstemmed Kidney Injury Caused by Preeclamptic Pregnancy Recovers Postpartum in a Transgenic Rat Model
title_short Kidney Injury Caused by Preeclamptic Pregnancy Recovers Postpartum in a Transgenic Rat Model
title_sort kidney injury caused by preeclamptic pregnancy recovers postpartum in a transgenic rat model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038582/
https://www.ncbi.nlm.nih.gov/pubmed/33916404
http://dx.doi.org/10.3390/ijms22073762
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