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Relationship between Orexigenic Peptide Ghrelin Signal, Gender Difference and Disease
Growth hormone secretagogue receptor 1a (GHS-R1a), which is one of the G protein-coupled receptors (GPCRs), is involved in various physiological actions such as energy consumption, growth hormone secretion promoting action, and cardiovascular protective action. The ligand was searched for as an orph...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038632/ https://www.ncbi.nlm.nih.gov/pubmed/33916403 http://dx.doi.org/10.3390/ijms22073763 |
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author | Yamada, Chihiro |
author_facet | Yamada, Chihiro |
author_sort | Yamada, Chihiro |
collection | PubMed |
description | Growth hormone secretagogue receptor 1a (GHS-R1a), which is one of the G protein-coupled receptors (GPCRs), is involved in various physiological actions such as energy consumption, growth hormone secretion promoting action, and cardiovascular protective action. The ligand was searched for as an orphan receptor for a while, but the ligand was found to be acylated ghrelin (ghrelin) discovered by Kangawa and Kojima et al. in 1999. Recently, it has also been reported that dysregulation of GHS-R1a mediates reduced feeding in various diseases. On the other hand, since the physiological effects of ghrelin have been studied exclusively in male mice, few studies have been conducted on gender differences in ghrelin reactivity. In this review, we describe (1) the characteristics of GHS-R1a, (2) the role of ghrelin in hypophagia due to stress or anticancer drugs, and (3) the gender differences in the physiological effects of GHS-R1a and the influence of stress on it. |
format | Online Article Text |
id | pubmed-8038632 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80386322021-04-12 Relationship between Orexigenic Peptide Ghrelin Signal, Gender Difference and Disease Yamada, Chihiro Int J Mol Sci Review Growth hormone secretagogue receptor 1a (GHS-R1a), which is one of the G protein-coupled receptors (GPCRs), is involved in various physiological actions such as energy consumption, growth hormone secretion promoting action, and cardiovascular protective action. The ligand was searched for as an orphan receptor for a while, but the ligand was found to be acylated ghrelin (ghrelin) discovered by Kangawa and Kojima et al. in 1999. Recently, it has also been reported that dysregulation of GHS-R1a mediates reduced feeding in various diseases. On the other hand, since the physiological effects of ghrelin have been studied exclusively in male mice, few studies have been conducted on gender differences in ghrelin reactivity. In this review, we describe (1) the characteristics of GHS-R1a, (2) the role of ghrelin in hypophagia due to stress or anticancer drugs, and (3) the gender differences in the physiological effects of GHS-R1a and the influence of stress on it. MDPI 2021-04-05 /pmc/articles/PMC8038632/ /pubmed/33916403 http://dx.doi.org/10.3390/ijms22073763 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yamada, Chihiro Relationship between Orexigenic Peptide Ghrelin Signal, Gender Difference and Disease |
title | Relationship between Orexigenic Peptide Ghrelin Signal, Gender Difference and Disease |
title_full | Relationship between Orexigenic Peptide Ghrelin Signal, Gender Difference and Disease |
title_fullStr | Relationship between Orexigenic Peptide Ghrelin Signal, Gender Difference and Disease |
title_full_unstemmed | Relationship between Orexigenic Peptide Ghrelin Signal, Gender Difference and Disease |
title_short | Relationship between Orexigenic Peptide Ghrelin Signal, Gender Difference and Disease |
title_sort | relationship between orexigenic peptide ghrelin signal, gender difference and disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038632/ https://www.ncbi.nlm.nih.gov/pubmed/33916403 http://dx.doi.org/10.3390/ijms22073763 |
work_keys_str_mv | AT yamadachihiro relationshipbetweenorexigenicpeptideghrelinsignalgenderdifferenceanddisease |