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In Vitro Activation Early Follicles: From the Basic Science to the Clinical Perspectives

Development of early follicles, especially the activation of primordial follicles, is strictly modulated by a network of signaling pathways. Recent advance in ovarian physiology has been allowed the development of several therapies to improve reproductive outcomes by manipulating early folliculogene...

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Detalles Bibliográficos
Autores principales: Vo, Kim Cat Tuyen, Kawamura, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038686/
https://www.ncbi.nlm.nih.gov/pubmed/33917468
http://dx.doi.org/10.3390/ijms22073785
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author Vo, Kim Cat Tuyen
Kawamura, Kazuhiro
author_facet Vo, Kim Cat Tuyen
Kawamura, Kazuhiro
author_sort Vo, Kim Cat Tuyen
collection PubMed
description Development of early follicles, especially the activation of primordial follicles, is strictly modulated by a network of signaling pathways. Recent advance in ovarian physiology has been allowed the development of several therapies to improve reproductive outcomes by manipulating early folliculogenesis. Among these, in vitro activation (IVA) has been recently developed to extend the possibility of achieving genetically related offspring for patients with premature ovarian insufficiency and ovarian dysfunction. This method was established based on basic science studies of the intraovarian signaling pathways: the phosphoinositide 3-kinase (PI3K)/Akt and the Hippo signaling pathways. These two pathways were found to play crucial roles in folliculogenesis from the primordial follicle to the early antral follicle. Following the results of rodent experiments, IVA was implemented in clinical practice. There have been multiple recorded live births and ongoing pregnancies. Further investigations are essential to confirm the efficacy and safety of IVA before used widely in clinics. This review aimed to summarize the published literature on IVA and provide future perspectives for its improvement.
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spelling pubmed-80386862021-04-12 In Vitro Activation Early Follicles: From the Basic Science to the Clinical Perspectives Vo, Kim Cat Tuyen Kawamura, Kazuhiro Int J Mol Sci Review Development of early follicles, especially the activation of primordial follicles, is strictly modulated by a network of signaling pathways. Recent advance in ovarian physiology has been allowed the development of several therapies to improve reproductive outcomes by manipulating early folliculogenesis. Among these, in vitro activation (IVA) has been recently developed to extend the possibility of achieving genetically related offspring for patients with premature ovarian insufficiency and ovarian dysfunction. This method was established based on basic science studies of the intraovarian signaling pathways: the phosphoinositide 3-kinase (PI3K)/Akt and the Hippo signaling pathways. These two pathways were found to play crucial roles in folliculogenesis from the primordial follicle to the early antral follicle. Following the results of rodent experiments, IVA was implemented in clinical practice. There have been multiple recorded live births and ongoing pregnancies. Further investigations are essential to confirm the efficacy and safety of IVA before used widely in clinics. This review aimed to summarize the published literature on IVA and provide future perspectives for its improvement. MDPI 2021-04-06 /pmc/articles/PMC8038686/ /pubmed/33917468 http://dx.doi.org/10.3390/ijms22073785 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vo, Kim Cat Tuyen
Kawamura, Kazuhiro
In Vitro Activation Early Follicles: From the Basic Science to the Clinical Perspectives
title In Vitro Activation Early Follicles: From the Basic Science to the Clinical Perspectives
title_full In Vitro Activation Early Follicles: From the Basic Science to the Clinical Perspectives
title_fullStr In Vitro Activation Early Follicles: From the Basic Science to the Clinical Perspectives
title_full_unstemmed In Vitro Activation Early Follicles: From the Basic Science to the Clinical Perspectives
title_short In Vitro Activation Early Follicles: From the Basic Science to the Clinical Perspectives
title_sort in vitro activation early follicles: from the basic science to the clinical perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038686/
https://www.ncbi.nlm.nih.gov/pubmed/33917468
http://dx.doi.org/10.3390/ijms22073785
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