Cargando…
Severe Tachycardia Associated with Psychotropic Medications in Psychiatric Inpatients: A Study of Hospital Medical Emergency Team Activation
The use of antipsychotic medications is associated with side effects, but the occurrence of severe tachycardia (heart rate ≥ 130 per minute) is not well described. The aim of this study was to determine the frequency and strength of the association between antipsychotic use and severe tachycardia in...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038822/ https://www.ncbi.nlm.nih.gov/pubmed/33917515 http://dx.doi.org/10.3390/jcm10071534 |
_version_ | 1783677464531173376 |
---|---|
author | Lim, Andy K. H. Azraai, Meor Pham, Jeanette H. Looi, Wenye F. Wirth, Daniel Ng, Ashley S. L. Babu, Umesh Saluja, Bharat |
author_facet | Lim, Andy K. H. Azraai, Meor Pham, Jeanette H. Looi, Wenye F. Wirth, Daniel Ng, Ashley S. L. Babu, Umesh Saluja, Bharat |
author_sort | Lim, Andy K. H. |
collection | PubMed |
description | The use of antipsychotic medications is associated with side effects, but the occurrence of severe tachycardia (heart rate ≥ 130 per minute) is not well described. The aim of this study was to determine the frequency and strength of the association between antipsychotic use and severe tachycardia in an inpatient population of patients with mental illness, while considering factors which may contribute to tachycardia. We retrospectively analyzed data from 636 Medical Emergency Team (MET) calls occurring in 449 psychiatry inpatients in three metropolitan hospitals co-located with acute medical services, and used mixed-effects logistic regression to model the association between severe tachycardia and antipsychotic use. The median age of patients was 42 years and 39% had a diagnosis of schizophrenia or psychotic disorder. Among patients who experienced MET calls, the use of second-generation (atypical) antipsychotics was commonly encountered (70%), but the use of first-generation (conventional) antipsychotics was less prevalent (10%). Severe tachycardia was noted in 22% of all MET calls, and sinus tachycardia was the commonest cardiac rhythm. After adjusting for age, anticholinergic medication use, temperature >38 °C and hypoglycemia, and excluding patients with infection and venous thromboembolism, the odds ratio for severe tachycardia with antipsychotic medication use was 4.09 (95% CI: 1.64 to 10.2). |
format | Online Article Text |
id | pubmed-8038822 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80388222021-04-12 Severe Tachycardia Associated with Psychotropic Medications in Psychiatric Inpatients: A Study of Hospital Medical Emergency Team Activation Lim, Andy K. H. Azraai, Meor Pham, Jeanette H. Looi, Wenye F. Wirth, Daniel Ng, Ashley S. L. Babu, Umesh Saluja, Bharat J Clin Med Article The use of antipsychotic medications is associated with side effects, but the occurrence of severe tachycardia (heart rate ≥ 130 per minute) is not well described. The aim of this study was to determine the frequency and strength of the association between antipsychotic use and severe tachycardia in an inpatient population of patients with mental illness, while considering factors which may contribute to tachycardia. We retrospectively analyzed data from 636 Medical Emergency Team (MET) calls occurring in 449 psychiatry inpatients in three metropolitan hospitals co-located with acute medical services, and used mixed-effects logistic regression to model the association between severe tachycardia and antipsychotic use. The median age of patients was 42 years and 39% had a diagnosis of schizophrenia or psychotic disorder. Among patients who experienced MET calls, the use of second-generation (atypical) antipsychotics was commonly encountered (70%), but the use of first-generation (conventional) antipsychotics was less prevalent (10%). Severe tachycardia was noted in 22% of all MET calls, and sinus tachycardia was the commonest cardiac rhythm. After adjusting for age, anticholinergic medication use, temperature >38 °C and hypoglycemia, and excluding patients with infection and venous thromboembolism, the odds ratio for severe tachycardia with antipsychotic medication use was 4.09 (95% CI: 1.64 to 10.2). MDPI 2021-04-06 /pmc/articles/PMC8038822/ /pubmed/33917515 http://dx.doi.org/10.3390/jcm10071534 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lim, Andy K. H. Azraai, Meor Pham, Jeanette H. Looi, Wenye F. Wirth, Daniel Ng, Ashley S. L. Babu, Umesh Saluja, Bharat Severe Tachycardia Associated with Psychotropic Medications in Psychiatric Inpatients: A Study of Hospital Medical Emergency Team Activation |
title | Severe Tachycardia Associated with Psychotropic Medications in Psychiatric Inpatients: A Study of Hospital Medical Emergency Team Activation |
title_full | Severe Tachycardia Associated with Psychotropic Medications in Psychiatric Inpatients: A Study of Hospital Medical Emergency Team Activation |
title_fullStr | Severe Tachycardia Associated with Psychotropic Medications in Psychiatric Inpatients: A Study of Hospital Medical Emergency Team Activation |
title_full_unstemmed | Severe Tachycardia Associated with Psychotropic Medications in Psychiatric Inpatients: A Study of Hospital Medical Emergency Team Activation |
title_short | Severe Tachycardia Associated with Psychotropic Medications in Psychiatric Inpatients: A Study of Hospital Medical Emergency Team Activation |
title_sort | severe tachycardia associated with psychotropic medications in psychiatric inpatients: a study of hospital medical emergency team activation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038822/ https://www.ncbi.nlm.nih.gov/pubmed/33917515 http://dx.doi.org/10.3390/jcm10071534 |
work_keys_str_mv | AT limandykh severetachycardiaassociatedwithpsychotropicmedicationsinpsychiatricinpatientsastudyofhospitalmedicalemergencyteamactivation AT azraaimeor severetachycardiaassociatedwithpsychotropicmedicationsinpsychiatricinpatientsastudyofhospitalmedicalemergencyteamactivation AT phamjeanetteh severetachycardiaassociatedwithpsychotropicmedicationsinpsychiatricinpatientsastudyofhospitalmedicalemergencyteamactivation AT looiwenyef severetachycardiaassociatedwithpsychotropicmedicationsinpsychiatricinpatientsastudyofhospitalmedicalemergencyteamactivation AT wirthdaniel severetachycardiaassociatedwithpsychotropicmedicationsinpsychiatricinpatientsastudyofhospitalmedicalemergencyteamactivation AT ngashleysl severetachycardiaassociatedwithpsychotropicmedicationsinpsychiatricinpatientsastudyofhospitalmedicalemergencyteamactivation AT babuumesh severetachycardiaassociatedwithpsychotropicmedicationsinpsychiatricinpatientsastudyofhospitalmedicalemergencyteamactivation AT salujabharat severetachycardiaassociatedwithpsychotropicmedicationsinpsychiatricinpatientsastudyofhospitalmedicalemergencyteamactivation |