Cargando…

β-Sitosterol Circumvents Obesity Induced Inflammation and Insulin Resistance by down-Regulating IKKβ/NF-κB and JNK Signaling Pathway in Adipocytes of Type 2 Diabetic Rats

β-sitosterol (SIT), the most abundant bioactive component of vegetable oil and other plants, is a highly potent antidiabetic drug. Our previous studies show that SIT controls hyperglycemia and insulin resistance by activating insulin receptor and glucose transporter 4 (GLUT-4) in the adipocytes of o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jayaraman, Selvaraj, Devarajan, Nalini, Rajagopal, Ponnulakshmi, Babu, Shyamaladevi, Ganesan, Senthil Kumar, Veeraraghavan, Vishnu Priya, Palanisamy, Chella Perumal, Cui, Bo, Periyasamy, Vijayalakshmi, Chandrasekar, Kirubhanand
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038823/ https://www.ncbi.nlm.nih.gov/pubmed/33917607 http://dx.doi.org/10.3390/molecules26072101

Ejemplares similares

Molecular docking data of piperine with Bax, Caspase 3, Cox 2 and Caspase 9
por: Kirubhanand, Chandrasekaran, et al.
Publicado: (2020)

Molecular docking analysis of Enterotoxin I from Staphylococcus aureus with Nafcillin analogues
por: Selvaraj, Jayaraman, et al.
Publicado: (2020)

Molecular docking analysis of Bcl-2 with phyto-compounds
por: Kirubhanand, Chandrasekaran, et al.
Publicado: (2020)

Docking analysis of importin-11 homology model with the phyto compounds towards colorectal cancer treatment
por: Selvaraj, Jayaraman, et al.
Publicado: (2020)

(5E,7E)-4,5,6 Trihydroxy-3-(hydroxymethyl)tetrahydro-2H-pyran-2-ylheptadeca-5,7-dienoate from Euclea crispa (L.) Inhibits Ovarian Cancer Cell Growth by Controlling Apoptotic and Metastatic Signaling Mechanisms
por: Palanisamy, Chella Perumal, et al.
Publicado: (2022)

Beta-Sitosterol Facilitates GLUT4 Vesicle Fusion on the Plasma Membrane via the Activation of Rab/IRAP/Munc 18 Signaling Pathways in Diabetic Gastrocnemius Muscle of Adult Male Rats
por: Pei, JinJin, et al.
Publicado: (2022)

Molecular docking analysis of aspirin analogues with β-catenin
por: Selvaraj, Jayaraman, et al.
Publicado: (2020)

Molecular docking analysis of docetaxel analogues as duel lipocalin 2 inhibitors
por: Ponnulakshmi, Rajagopal, et al.
Publicado: (2020)

Molecular docking analysis of metformin analogues with GSK-3β
por: Rajagopal, Ponnu lakshmi, et al.
Publicado: (2022)

Molecular docking analysis of flavonoids with aldose reductase
por: Kannayiram, Kasthuri, et al.
Publicado: (2022)

MTT assay based inhibition analysis of A2780 cells proliferation using Mollugo nudicaulis Lam. extract with CXCR4 and HER2 expression
por: Palanisamy, Chella Perumal, et al.
Publicado: (2021)

Molecular docking analysis of bioactive compounds from Plectranthus amboinicus with glucokinase
por: Vidhya Rekha, Umapathy, et al.
Publicado: (2022)

Molecular docking analysis of alkaloid compounds with beta-catenin towards the treatment of colon cancer
por: Ponnulakshmi, Rajagopal, et al.
Publicado: (2020)

The porin AaxA protein model from Chlamydia pneumonia
por: Selvaraj, Jayaraman, et al.
Publicado: (2020)

A Review of the Potential Consequences of Pearl Millet (Pennisetum glaucum) for Diabetes Mellitus and Other Biomedical Applications
por: Pei, JinJin, et al.
Publicado: (2022)

Molecular docking analysis of beta-catenin with compounds derived from Lycopersicon esculentum
por: Selvaraj, Jayaraman, et al.
Publicado: (2020)

Molecular docking analysis of COX-2 for potential inhibitors
por: Selvaraj, Jayaraman, et al.
Publicado: (2020)

Molecular docking analysis of amyloid precursor protein with compounds from the Australian cowplant
por: Selvaraj, Jayaraman, et al.
Publicado: (2020)

Molecular docking analysis of bioactive compounds from Cissampelos pareira with PPAR gamma
por: Vidhya Rekha, Umapathy, et al.
Publicado: (2022)

β-sitosterol Mediated Silver Nanoparticles Induce Cytotoxicity in Human Colon Cancer HT-29 Cells
por: Shathviha, Palaniappan Chithambara, et al.
Publicado: (2021)

Stevioside Attenuates Insulin Resistance in Skeletal Muscle by Facilitating IR/IRS-1/Akt/GLUT 4 Signaling Pathways: An In Vivo and In Silico Approach
por: Deenadayalan, Abilasha, et al.
Publicado: (2021)

A Comprehensive Review on Bio-Based Materials for Chronic Diabetic Wounds
por: Pei, Jinjin, et al.
Publicado: (2023)

Molecular modeling of cornulin (CRNN) for docking with phytocompounds from Justicia adhatoda L.
por: Selvaraj, Jayaraman, et al.
Publicado: (2021)

Molecular docking of potential inhibitors with the mTOR protein
por: Fathima, JH Shazia, et al.
Publicado: (2021)

Molecular docking analysis of compounds from Justica adhatoda L with glycogen synthase kinase-3 β
por: Jayaraman, Selvaraj, et al.
Publicado: (2020)

Nigella sativa L. seed extracts promote wound healing progress by activating VEGF and PDGF signaling pathways: An in vitro and in silico study
por: Palanisamy, Chella Perumal, et al.
Publicado: (2023)

Effect of β-sitosterol self-microemulsion and β-sitosterol ester with linoleic acid on lipid-lowering in hyperlipidemic mice
por: Yuan, Chuanxun, et al.
Publicado: (2019)

Anti-Hepatocellular-Cancer Activity Exerted by β-Sitosterol and β-Sitosterol-Glucoside from Indigofera zollingeriana Miq
por: Vo, Tuong Kha, et al.
Publicado: (2020)

Molecular docking analysis of glycogen phosphorylase with inhibitors from Cissampelos pareira Linn.
por: Chandrashekar, Kirubhanand, et al.
Publicado: (2021)

A Comprehensive Review on Corn Starch-Based Nanomaterials: Properties, Simulations, and Applications
por: Palanisamy, Chella Perumal, et al.
Publicado: (2020)

A Comprehensive Review on Therapeutic Perspectives of Phytosterols in Insulin Resistance: A Mechanistic Approach
por: Prasad, Monisha, et al.
Publicado: (2022)

Effect of β-sitosterol on insulin resistance & protein expression of insulin signalling molecules in quadriceps muscle of high fat diet-induced type-2 diabetic rats
por: Sekar, Gayathri, et al.
Publicado: (2022)

Modulating the Effect of β-Sitosterol Conjugated with Magnetic Nanocarriers to Inhibit EGFR and Met Receptor Cross Talk
por: Ilangovan, Shanmuga Sundari, et al.
Publicado: (2023)

Carica Papaya Reduces High Fat Diet and Streptozotocin-Induced Development of Inflammation in Adipocyte via IL-1β/IL-6/TNF-α Mediated Signaling Mechanisms in Type-2 Diabetic Rats
por: Rebecca Roy, Jeane, et al.
Publicado: (2023)

Targeting IKKβ in Cancer: Challenges and Opportunities for the Therapeutic Utilisation of IKKβ Inhibitors
por: Prescott, Jack A., et al.
Publicado: (2018)

Impact of Glyphosate on the Development of Insulin Resistance in Experimental Diabetic Rats: Role of NFκB Signalling Pathways
por: Prasad, Monisha, et al.
Publicado: (2022)

Isolation of β-sitosterol diglucosyl caprate from Alpinia galanga
por: Jaju, S. B., et al.
Publicado: (2010)

The Phase Behavior of γ-Oryzanol and β-Sitosterol in Edible Oil
por: Sawalha, Hassan, et al.
Publicado: (2015)

β-sitosterol interacts with pneumolysin to prevent Streptococcus pneumoniae infection
por: Li, Hongen, et al.
Publicado: (2015)

Molecular Mechanism of β-Sitosterol and its Derivatives in Tumor Progression
por: Bao, Xingxun, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_a7g7esj2gacd3ms6lktfrtef7l