The Presence of a Cyclohexyldiamine Moiety Confers Cytotoxicity to Pentacyclic Triterpenoids

Pentacyclic triterpenoids oleanolic acid, ursolic acid, betulinic acid, and platanic acid were acetylated and converted into several amides 9–31; the cytotoxicity of which has been determined in sulforhodamine B assays employing seral human tumor cell lines and nonmalignant fibroblasts. Thereby, a b...

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Autores principales: Hoenke, Sophie, Christoph, Martin A., Friedrich, Sander, Heise, Niels, Brandes, Benjamin, Deigner, Hans-Peter, Al-Harrasi, Ahmed, Csuk, René
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038856/
https://www.ncbi.nlm.nih.gov/pubmed/33917636
http://dx.doi.org/10.3390/molecules26072102
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author Hoenke, Sophie
Christoph, Martin A.
Friedrich, Sander
Heise, Niels
Brandes, Benjamin
Deigner, Hans-Peter
Al-Harrasi, Ahmed
Csuk, René
author_facet Hoenke, Sophie
Christoph, Martin A.
Friedrich, Sander
Heise, Niels
Brandes, Benjamin
Deigner, Hans-Peter
Al-Harrasi, Ahmed
Csuk, René
author_sort Hoenke, Sophie
collection PubMed
description Pentacyclic triterpenoids oleanolic acid, ursolic acid, betulinic acid, and platanic acid were acetylated and converted into several amides 9–31; the cytotoxicity of which has been determined in sulforhodamine B assays employing seral human tumor cell lines and nonmalignant fibroblasts. Thereby, a betulinic acid/trans-1,4-cyclohexyldiamine amide showed excellent cytotoxicity (for example, EC(50) = 0.6 μM for HT29 colon adenocarcinoma cells).
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spelling pubmed-80388562021-04-12 The Presence of a Cyclohexyldiamine Moiety Confers Cytotoxicity to Pentacyclic Triterpenoids Hoenke, Sophie Christoph, Martin A. Friedrich, Sander Heise, Niels Brandes, Benjamin Deigner, Hans-Peter Al-Harrasi, Ahmed Csuk, René Molecules Article Pentacyclic triterpenoids oleanolic acid, ursolic acid, betulinic acid, and platanic acid were acetylated and converted into several amides 9–31; the cytotoxicity of which has been determined in sulforhodamine B assays employing seral human tumor cell lines and nonmalignant fibroblasts. Thereby, a betulinic acid/trans-1,4-cyclohexyldiamine amide showed excellent cytotoxicity (for example, EC(50) = 0.6 μM for HT29 colon adenocarcinoma cells). MDPI 2021-04-06 /pmc/articles/PMC8038856/ /pubmed/33917636 http://dx.doi.org/10.3390/molecules26072102 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hoenke, Sophie
Christoph, Martin A.
Friedrich, Sander
Heise, Niels
Brandes, Benjamin
Deigner, Hans-Peter
Al-Harrasi, Ahmed
Csuk, René
The Presence of a Cyclohexyldiamine Moiety Confers Cytotoxicity to Pentacyclic Triterpenoids
title The Presence of a Cyclohexyldiamine Moiety Confers Cytotoxicity to Pentacyclic Triterpenoids
title_full The Presence of a Cyclohexyldiamine Moiety Confers Cytotoxicity to Pentacyclic Triterpenoids
title_fullStr The Presence of a Cyclohexyldiamine Moiety Confers Cytotoxicity to Pentacyclic Triterpenoids
title_full_unstemmed The Presence of a Cyclohexyldiamine Moiety Confers Cytotoxicity to Pentacyclic Triterpenoids
title_short The Presence of a Cyclohexyldiamine Moiety Confers Cytotoxicity to Pentacyclic Triterpenoids
title_sort presence of a cyclohexyldiamine moiety confers cytotoxicity to pentacyclic triterpenoids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038856/
https://www.ncbi.nlm.nih.gov/pubmed/33917636
http://dx.doi.org/10.3390/molecules26072102
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