Cargando…

The Presence of a Cyclohexyldiamine Moiety Confers Cytotoxicity to Pentacyclic Triterpenoids

Pentacyclic triterpenoids oleanolic acid, ursolic acid, betulinic acid, and platanic acid were acetylated and converted into several amides 9–31; the cytotoxicity of which has been determined in sulforhodamine B assays employing seral human tumor cell lines and nonmalignant fibroblasts. Thereby, a b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hoenke, Sophie, Christoph, Martin A., Friedrich, Sander, Heise, Niels, Brandes, Benjamin, Deigner, Hans-Peter, Al-Harrasi, Ahmed, Csuk, René
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038856/ https://www.ncbi.nlm.nih.gov/pubmed/33917636 http://dx.doi.org/10.3390/molecules26072102

Ejemplares similares

Mitocanic Di- and Triterpenoid Rhodamine B Conjugates
por: Hoenke, Sophie, et al.
Publicado: (2020)

Developing an Amide-Spacered Triterpenoid Rhodamine Hybrid of Nano-Molar Cytotoxicity Combined with Excellent Tumor Cell/Non-Tumor Cell Selectivity
por: Heise, Niels V., et al.
Publicado: (2023)

Cytotoxic Potential of a-Azepano- and 3-Amino-3,4-SeCo-Triterpenoids
por: Kazakova, Oxana, et al.
Publicado: (2021)

The Finally Rewarding Search for A Cytotoxic Isosteviol Derivative
por: Heisig, Julia, et al.
Publicado: (2023)

Synthesis and Cytotoxicity Evaluation of DOTA-Conjugates of Ursolic Acid
por: Kahnt, Michael, et al.
Publicado: (2019)

Rhodamine 101 Conjugates of Triterpenoic Amides Are of Comparable Cytotoxicity as Their Rhodamine B Analogs
por: Heise, Niels V., et al.
Publicado: (2022)

Small Structural Differences Govern the Carbonic Anhydrase II Inhibition Activity of Cytotoxic Triterpene Acetazolamide Conjugates
por: Denner, Toni C., et al.
Publicado: (2023)

Pentacyclic Triterpenoids with Nitrogen-Containing Heterocyclic Moiety, Privileged Hybrids in Anticancer Drug Discovery
por: Khwaza, Vuyolwethu, et al.
Publicado: (2021)

Bioinspired synthesis of pentacyclic onocerane triterpenoids
por: Bartels, Florian, et al.
Publicado: (2017)

Synthesis and In Silico Docking of New Pyrazolo[4,3-e]pyrido[1,2-a]pyrimidine-based Cytotoxic Agents
por: Horchani, Mabrouk, et al.
Publicado: (2021)

Concise Synthesis of Both Enantiomers of Pilocarpine
por: Schmidt, Theresa, et al.
Publicado: (2021)

Nanoformulations for Delivery of Pentacyclic Triterpenoids in Anticancer Therapies
por: Kaps, Anna, et al.
Publicado: (2021)

Madecassic Acid—A New Scaffold for Highly Cytotoxic Agents
por: Kraft, Oliver, et al.
Publicado: (2022)

Diterpenoids and Triterpenoids From Frankincense Are Excellent Anti-psoriatic Agents: An in silico Approach
por: Halim, Sobia Ahsan, et al.
Publicado: (2020)

Transcriptional Profiles of the Response of Methicillin-Resistant Staphylococcus aureus to Pentacyclic Triterpenoids
por: Chung, Pooi Yin, et al.
Publicado: (2013)

Bauerenol Acetate, the Pentacyclic Triterpenoid from Tabernaemontana longipes, is an Antitrypanosomal Agent
por: Carothers, Simira, et al.
Publicado: (2018)

Pentacyclic Triterpenoids from the Medicinal Herb, Centella asiatica (L.) Urban
por: James, Jacinda T., et al.
Publicado: (2009)

Antibacterial and Synergistic Activity of Pentacyclic Triterpenoids Isolated from Alstonia scholaris
por: Wang, Chao-Min, et al.
Publicado: (2016)

Role of Pentacyclic Triterpenoids in Chemoprevention and Anticancer Treatment: An Overview on Targets and Underling Mechanisms
por: Ghante, Mahavir H., et al.
Publicado: (2019)

Ursolic Acid—A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities
por: Woźniak, Łukasz, et al.
Publicado: (2015)

Pentacyclic Triterpenoids from Sabia discolor Dunn and Their α-Glycosidase Inhibitory Activities
por: Ma, Jin-Hong, et al.
Publicado: (2022)

The pentacyclic triterpenoid phytosterol lupeol promotes antioxidant response in the nematode C. elegans
por: Voia, Anna, et al.
Publicado: (2022)

Pentacyclic Triterpenoid Phytochemicals with Anticancer Activity: Updated Studies on Mechanisms and Targeted Delivery
por: Nistor, Madalina, et al.
Publicado: (2023)

Semisynthetic Derivatives of Pentacyclic Triterpenes Bearing Heterocyclic Moieties with Therapeutic Potential
por: Nistor, Gabriela, et al.
Publicado: (2022)

Synergistic antimicrobial activity between pentacyclic triterpenoids and antibiotics against Staphylococcus aureus strains
por: Chung, Pooi Yin, et al.
Publicado: (2011)

In Vitro Antioxidant Activity Potential of Lantadene A, a Pentacyclic Triterpenoid of Lantana Plants
por: Grace-Lynn, Chong, et al.
Publicado: (2012)

Neutrophil elastase inhibitory effects of pentacyclic triterpenoids from Eriobotrya japonica (loquat leaves)
por: Zhang, Jie, et al.
Publicado: (2019)

Pentacyclic Triterpenoids Isolated from Celastraceae: A Focus in the (13)C-NMR Data
por: Camargo, Karen Caroline, et al.
Publicado: (2022)

Metabolite and Gene Expression Analysis Underlying Temporal and Spatial Accumulation of Pentacyclic Triterpenoids in Jujube
por: Wen, Cuiping, et al.
Publicado: (2022)

Pharmacological Features of 18β-Glycyrrhetinic Acid: A Pentacyclic Triterpenoid of Therapeutic Potential
por: Shinu, Pottathil, et al.
Publicado: (2023)

Four New Unusual Pentacyclic Triterpenoids from the Roots of Jasminum sambac (L.) Ait
por: Olatunde, Olagoke Zacchaeus, et al.
Publicado: (2023)

Structure-Activity Relationships of Pentacyclic Triterpenoids as Potent and Selective Inhibitors against Human Carboxylesterase 1
por: Zou, Li-Wei, et al.
Publicado: (2017)

Supercritical Fluid Chromatography—Tandem Mass Spectrometry for Rapid Quantification of Pentacyclic Triterpenoids in Plant Extracts
por: Falev, Danil I., et al.
Publicado: (2022)

Parallel damage in mitochondrial and lysosomal compartments promotes efficient cell death with autophagy: The case of the pentacyclic triterpenoids
por: Martins, Waleska K., et al.
Publicado: (2015)

Exploring the Chemical Diversity of Algerian Plants: Three New Pentacyclic Triterpenoids from Launaea acanthoclada Roots
por: Zergainoh, Nabila, et al.
Publicado: (2017)

Pharmacological Properties, Molecular Mechanisms, and Pharmaceutical Development of Asiatic Acid: A Pentacyclic Triterpenoid of Therapeutic Promise
por: Nagoor Meeran, Mohamed Fizur, et al.
Publicado: (2018)

Cell-Free Production of Pentacyclic Triterpenoid Compound Betulinic Acid from Betulin by the Engineered Saccharomyces cerevisiae
por: Wu, Jianan, et al.
Publicado: (2017)

Site-selective C-H hydroxylation of pentacyclic triterpenoids directed by transient chiral pyridine-imino groups
por: Mu, Tong, et al.
Publicado: (2020)

A telomere-to-telomere reference genome provides genetic insight into the pentacyclic triterpenoid biosynthesis in Chaenomeles speciosa
por: He, Shaofang, et al.
Publicado: (2023)

Determination of Pentacyclic Triterpenoids in Plant Biomass by Porous Graphitic Carbon Liquid Chromatography—Tandem Mass Spectrometry
por: Voronov, Ilya S., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_8tkmobshr6ko92d6u6od4m5edt