HMEJ-based safe-harbor genome editing enables efficient generation of cattle with increased resistance to tuberculosis

The CRISPR/Cas9 system has been used in a wide range of applications in the production of gene-edited animals and plants. Most efforts to insert genes have relied on homology-directed repair (HDR)-mediated integration, but this strategy remains inefficient for the production of gene-edited livestock...

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Detalles Bibliográficos
Autores principales: Yuan, Mengke, Zhang, Jingcheng, Gao, Yuanpeng, Yuan, Zikun, Zhu, Zhenliang, Wei, Yongke, Wu, Teng, Han, Jing, Zhang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Methods and Resources
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038940/
https://www.ncbi.nlm.nih.gov/pubmed/33675752
http://dx.doi.org/10.1016/j.jbc.2021.100497

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