Human-chimpanzee fused cells reveal cis-regulatory divergence underlying skeletal evolution

Gene regulatory divergence is thought to play a central role in determining human-specific traits. However, our ability to link divergent regulation to divergent phenotypes is limited. Here, we utilized human-chimpanzee hybrid induced pluripotent stem cells to study gene expression separating these...

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Detalles Bibliográficos
Autores principales: Gokhman, David, Agoglia, Rachel M., Kinnebrew, Maia, Gordon, Wei, Sun, Danqiong, Bajpai, Vivek K., Naqvi, Sahin, Chen, Coral, Chan, Anthony, Chen, Chider, Petrov, Dmitri A., Ahituv, Nadav, Zhang, Honghao, Mishina, Yuji, Wysocka, Joanna, Rohatgi, Rajat, Fraser, Hunter B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038968/
https://www.ncbi.nlm.nih.gov/pubmed/33731941
http://dx.doi.org/10.1038/s41588-021-00804-3

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