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Prenatal Relocation Stress Enhances Resilience Under Challenge in Infant Rhesus Macaques
The prenatal period is a developmental stage of peak sensitivity, during which environmental exposures can program post-natal developmental outcomes. Prenatal stress, in particular, has often been associated with detrimental neurobehavioral outcomes like mood and anxiety disorders. In the present st...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039121/ https://www.ncbi.nlm.nih.gov/pubmed/33854420 http://dx.doi.org/10.3389/fnbeh.2021.641795 |
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author | Ceniceros, Lesly C. Capitanio, John P. Kinnally, Erin L. |
author_facet | Ceniceros, Lesly C. Capitanio, John P. Kinnally, Erin L. |
author_sort | Ceniceros, Lesly C. |
collection | PubMed |
description | The prenatal period is a developmental stage of peak sensitivity, during which environmental exposures can program post-natal developmental outcomes. Prenatal stress, in particular, has often been associated with detrimental neurobehavioral outcomes like mood and anxiety disorders. In the present study, we examined the effects of a stressful prenatal maternal experience (maternal relocation during pregnancy) on the post-partum development of offspring in rhesus macaques. To help isolate the effects of prenatal stress from genetic predispositions and post-natal experience, we compared biologically reared infants (infants raised with their biological mothers) with cross-fostered infants (those raised by non-related females in new social groups). We examined the effects of prenatal relocation stress on measures collected at 3–4 months of age during a standardized biobehavioral assessment. Unexpectedly, we found that prenatal stress resulted in a behavioral pattern consistent with resilience rather than anxiety: prenatal stress was linked with greater activity, lower anxiety, and more interaction with novel objects, as well as higher ratings of temperamental confidence during assessment. These effects were observed in infants reared by biological mothers as well as cross-fostered infants, suggesting that the effects of prenatal stress were not attributable to maternal genetics or post-natal factors. Our surprising results suggest that prenatal relocation stress may confer resilience in infant rhesus monkeys. |
format | Online Article Text |
id | pubmed-8039121 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80391212021-04-13 Prenatal Relocation Stress Enhances Resilience Under Challenge in Infant Rhesus Macaques Ceniceros, Lesly C. Capitanio, John P. Kinnally, Erin L. Front Behav Neurosci Behavioral Neuroscience The prenatal period is a developmental stage of peak sensitivity, during which environmental exposures can program post-natal developmental outcomes. Prenatal stress, in particular, has often been associated with detrimental neurobehavioral outcomes like mood and anxiety disorders. In the present study, we examined the effects of a stressful prenatal maternal experience (maternal relocation during pregnancy) on the post-partum development of offspring in rhesus macaques. To help isolate the effects of prenatal stress from genetic predispositions and post-natal experience, we compared biologically reared infants (infants raised with their biological mothers) with cross-fostered infants (those raised by non-related females in new social groups). We examined the effects of prenatal relocation stress on measures collected at 3–4 months of age during a standardized biobehavioral assessment. Unexpectedly, we found that prenatal stress resulted in a behavioral pattern consistent with resilience rather than anxiety: prenatal stress was linked with greater activity, lower anxiety, and more interaction with novel objects, as well as higher ratings of temperamental confidence during assessment. These effects were observed in infants reared by biological mothers as well as cross-fostered infants, suggesting that the effects of prenatal stress were not attributable to maternal genetics or post-natal factors. Our surprising results suggest that prenatal relocation stress may confer resilience in infant rhesus monkeys. Frontiers Media S.A. 2021-03-29 /pmc/articles/PMC8039121/ /pubmed/33854420 http://dx.doi.org/10.3389/fnbeh.2021.641795 Text en Copyright © 2021 Ceniceros, Capitanio and Kinnally. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Behavioral Neuroscience Ceniceros, Lesly C. Capitanio, John P. Kinnally, Erin L. Prenatal Relocation Stress Enhances Resilience Under Challenge in Infant Rhesus Macaques |
title | Prenatal Relocation Stress Enhances Resilience Under Challenge in Infant Rhesus Macaques |
title_full | Prenatal Relocation Stress Enhances Resilience Under Challenge in Infant Rhesus Macaques |
title_fullStr | Prenatal Relocation Stress Enhances Resilience Under Challenge in Infant Rhesus Macaques |
title_full_unstemmed | Prenatal Relocation Stress Enhances Resilience Under Challenge in Infant Rhesus Macaques |
title_short | Prenatal Relocation Stress Enhances Resilience Under Challenge in Infant Rhesus Macaques |
title_sort | prenatal relocation stress enhances resilience under challenge in infant rhesus macaques |
topic | Behavioral Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039121/ https://www.ncbi.nlm.nih.gov/pubmed/33854420 http://dx.doi.org/10.3389/fnbeh.2021.641795 |
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