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Advances in Understanding the LncRNA-Mediated Regulation of the Hippo Pathway in Cancer
Long noncoding RNAs (lncRNAs) are a class of RNA molecules that are longer than 200 nucleotides and cannot encode proteins. Over the past decade, lncRNAs have been defined as regulatory elements of multiple biological processes, and their aberrant expression contributes to the development and progre...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039192/ https://www.ncbi.nlm.nih.gov/pubmed/33854336 http://dx.doi.org/10.2147/OTT.S283157 |
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author | Wang, Mengwei Xu, Tianwei Feng, Wenyan Liu, Junxia Wang, Zhaoxia |
author_facet | Wang, Mengwei Xu, Tianwei Feng, Wenyan Liu, Junxia Wang, Zhaoxia |
author_sort | Wang, Mengwei |
collection | PubMed |
description | Long noncoding RNAs (lncRNAs) are a class of RNA molecules that are longer than 200 nucleotides and cannot encode proteins. Over the past decade, lncRNAs have been defined as regulatory elements of multiple biological processes, and their aberrant expression contributes to the development and progression of various malignancies. Recent studies have shown that lncRNAs are involved in key cancer-related signaling pathways, including the Hippo signaling pathway, which plays a prominent role in controlling organ size and tissue homeostasis by regulating cell proliferation, apoptosis, and differentiation. However, dysregulation of this pathway is associated with pathological conditions, especially cancer. Accumulating evidence has revealed that lncRNAs can modulate the Hippo signaling pathway in cancer. In this review, we elaborate on the role of the Hippo signaling pathway and the advances in the understanding of its lncRNA-mediated regulation in cancer. This review provides additional insight into carcinogenesis and will be of great clinical value for developing novel early detection and treatment strategies for this deadly disease. |
format | Online Article Text |
id | pubmed-8039192 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-80391922021-04-13 Advances in Understanding the LncRNA-Mediated Regulation of the Hippo Pathway in Cancer Wang, Mengwei Xu, Tianwei Feng, Wenyan Liu, Junxia Wang, Zhaoxia Onco Targets Ther Review Long noncoding RNAs (lncRNAs) are a class of RNA molecules that are longer than 200 nucleotides and cannot encode proteins. Over the past decade, lncRNAs have been defined as regulatory elements of multiple biological processes, and their aberrant expression contributes to the development and progression of various malignancies. Recent studies have shown that lncRNAs are involved in key cancer-related signaling pathways, including the Hippo signaling pathway, which plays a prominent role in controlling organ size and tissue homeostasis by regulating cell proliferation, apoptosis, and differentiation. However, dysregulation of this pathway is associated with pathological conditions, especially cancer. Accumulating evidence has revealed that lncRNAs can modulate the Hippo signaling pathway in cancer. In this review, we elaborate on the role of the Hippo signaling pathway and the advances in the understanding of its lncRNA-mediated regulation in cancer. This review provides additional insight into carcinogenesis and will be of great clinical value for developing novel early detection and treatment strategies for this deadly disease. Dove 2021-04-07 /pmc/articles/PMC8039192/ /pubmed/33854336 http://dx.doi.org/10.2147/OTT.S283157 Text en © 2021 Wang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Wang, Mengwei Xu, Tianwei Feng, Wenyan Liu, Junxia Wang, Zhaoxia Advances in Understanding the LncRNA-Mediated Regulation of the Hippo Pathway in Cancer |
title | Advances in Understanding the LncRNA-Mediated Regulation of the Hippo Pathway in Cancer |
title_full | Advances in Understanding the LncRNA-Mediated Regulation of the Hippo Pathway in Cancer |
title_fullStr | Advances in Understanding the LncRNA-Mediated Regulation of the Hippo Pathway in Cancer |
title_full_unstemmed | Advances in Understanding the LncRNA-Mediated Regulation of the Hippo Pathway in Cancer |
title_short | Advances in Understanding the LncRNA-Mediated Regulation of the Hippo Pathway in Cancer |
title_sort | advances in understanding the lncrna-mediated regulation of the hippo pathway in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039192/ https://www.ncbi.nlm.nih.gov/pubmed/33854336 http://dx.doi.org/10.2147/OTT.S283157 |
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