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Advances in Understanding the LncRNA-Mediated Regulation of the Hippo Pathway in Cancer

Long noncoding RNAs (lncRNAs) are a class of RNA molecules that are longer than 200 nucleotides and cannot encode proteins. Over the past decade, lncRNAs have been defined as regulatory elements of multiple biological processes, and their aberrant expression contributes to the development and progre...

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Detalles Bibliográficos
Autores principales: Wang, Mengwei, Xu, Tianwei, Feng, Wenyan, Liu, Junxia, Wang, Zhaoxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039192/
https://www.ncbi.nlm.nih.gov/pubmed/33854336
http://dx.doi.org/10.2147/OTT.S283157
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author Wang, Mengwei
Xu, Tianwei
Feng, Wenyan
Liu, Junxia
Wang, Zhaoxia
author_facet Wang, Mengwei
Xu, Tianwei
Feng, Wenyan
Liu, Junxia
Wang, Zhaoxia
author_sort Wang, Mengwei
collection PubMed
description Long noncoding RNAs (lncRNAs) are a class of RNA molecules that are longer than 200 nucleotides and cannot encode proteins. Over the past decade, lncRNAs have been defined as regulatory elements of multiple biological processes, and their aberrant expression contributes to the development and progression of various malignancies. Recent studies have shown that lncRNAs are involved in key cancer-related signaling pathways, including the Hippo signaling pathway, which plays a prominent role in controlling organ size and tissue homeostasis by regulating cell proliferation, apoptosis, and differentiation. However, dysregulation of this pathway is associated with pathological conditions, especially cancer. Accumulating evidence has revealed that lncRNAs can modulate the Hippo signaling pathway in cancer. In this review, we elaborate on the role of the Hippo signaling pathway and the advances in the understanding of its lncRNA-mediated regulation in cancer. This review provides additional insight into carcinogenesis and will be of great clinical value for developing novel early detection and treatment strategies for this deadly disease.
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spelling pubmed-80391922021-04-13 Advances in Understanding the LncRNA-Mediated Regulation of the Hippo Pathway in Cancer Wang, Mengwei Xu, Tianwei Feng, Wenyan Liu, Junxia Wang, Zhaoxia Onco Targets Ther Review Long noncoding RNAs (lncRNAs) are a class of RNA molecules that are longer than 200 nucleotides and cannot encode proteins. Over the past decade, lncRNAs have been defined as regulatory elements of multiple biological processes, and their aberrant expression contributes to the development and progression of various malignancies. Recent studies have shown that lncRNAs are involved in key cancer-related signaling pathways, including the Hippo signaling pathway, which plays a prominent role in controlling organ size and tissue homeostasis by regulating cell proliferation, apoptosis, and differentiation. However, dysregulation of this pathway is associated with pathological conditions, especially cancer. Accumulating evidence has revealed that lncRNAs can modulate the Hippo signaling pathway in cancer. In this review, we elaborate on the role of the Hippo signaling pathway and the advances in the understanding of its lncRNA-mediated regulation in cancer. This review provides additional insight into carcinogenesis and will be of great clinical value for developing novel early detection and treatment strategies for this deadly disease. Dove 2021-04-07 /pmc/articles/PMC8039192/ /pubmed/33854336 http://dx.doi.org/10.2147/OTT.S283157 Text en © 2021 Wang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Wang, Mengwei
Xu, Tianwei
Feng, Wenyan
Liu, Junxia
Wang, Zhaoxia
Advances in Understanding the LncRNA-Mediated Regulation of the Hippo Pathway in Cancer
title Advances in Understanding the LncRNA-Mediated Regulation of the Hippo Pathway in Cancer
title_full Advances in Understanding the LncRNA-Mediated Regulation of the Hippo Pathway in Cancer
title_fullStr Advances in Understanding the LncRNA-Mediated Regulation of the Hippo Pathway in Cancer
title_full_unstemmed Advances in Understanding the LncRNA-Mediated Regulation of the Hippo Pathway in Cancer
title_short Advances in Understanding the LncRNA-Mediated Regulation of the Hippo Pathway in Cancer
title_sort advances in understanding the lncrna-mediated regulation of the hippo pathway in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039192/
https://www.ncbi.nlm.nih.gov/pubmed/33854336
http://dx.doi.org/10.2147/OTT.S283157
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