Tip of the Iceberg: Roles of CircRNAs in Cancer Glycolysis

Warburg effect reflects that tumor cells tend to generate energy by aerobic glycolysis rather than oxidative phosphorylation (OXPHOS), thus promoting the development of malignant tumors. As a kind of non-coding RNA, circular RNA (circRNA) is characterized by a closed ring structure and emerges as a...

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Detalles Bibliográficos
Autores principales: Li, Tan, Xian, Hong-chun, Dai, Li, Tang, Ya-ling, Liang, Xin-hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039208/
https://www.ncbi.nlm.nih.gov/pubmed/33854335
http://dx.doi.org/10.2147/OTT.S297140
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author Li, Tan
Xian, Hong-chun
Dai, Li
Tang, Ya-ling
Liang, Xin-hua
author_facet Li, Tan
Xian, Hong-chun
Dai, Li
Tang, Ya-ling
Liang, Xin-hua
author_sort Li, Tan
collection PubMed
description Warburg effect reflects that tumor cells tend to generate energy by aerobic glycolysis rather than oxidative phosphorylation (OXPHOS), thus promoting the development of malignant tumors. As a kind of non-coding RNA, circular RNA (circRNA) is characterized by a closed ring structure and emerges as a regulator of cancer metabolism. Mounting studies revealed that circRNA can regulate the cancer metabolism process through affecting the expression of glycolysis relevant enzymes, transcription factors (TFs), and signaling pathways. In this review, we comprehensively analyzed and concluded the mechanism of circRNA regulating glycolysis, hoping to deepen the cognition of the cancer metabolic regulatory network and to reap huge fruits in targeted cancer treatment.
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spelling pubmed-80392082021-04-13 Tip of the Iceberg: Roles of CircRNAs in Cancer Glycolysis Li, Tan Xian, Hong-chun Dai, Li Tang, Ya-ling Liang, Xin-hua Onco Targets Ther Review Warburg effect reflects that tumor cells tend to generate energy by aerobic glycolysis rather than oxidative phosphorylation (OXPHOS), thus promoting the development of malignant tumors. As a kind of non-coding RNA, circular RNA (circRNA) is characterized by a closed ring structure and emerges as a regulator of cancer metabolism. Mounting studies revealed that circRNA can regulate the cancer metabolism process through affecting the expression of glycolysis relevant enzymes, transcription factors (TFs), and signaling pathways. In this review, we comprehensively analyzed and concluded the mechanism of circRNA regulating glycolysis, hoping to deepen the cognition of the cancer metabolic regulatory network and to reap huge fruits in targeted cancer treatment. Dove 2021-04-07 /pmc/articles/PMC8039208/ /pubmed/33854335 http://dx.doi.org/10.2147/OTT.S297140 Text en © 2021 Li et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Li, Tan
Xian, Hong-chun
Dai, Li
Tang, Ya-ling
Liang, Xin-hua
Tip of the Iceberg: Roles of CircRNAs in Cancer Glycolysis
title Tip of the Iceberg: Roles of CircRNAs in Cancer Glycolysis
title_full Tip of the Iceberg: Roles of CircRNAs in Cancer Glycolysis
title_fullStr Tip of the Iceberg: Roles of CircRNAs in Cancer Glycolysis
title_full_unstemmed Tip of the Iceberg: Roles of CircRNAs in Cancer Glycolysis
title_short Tip of the Iceberg: Roles of CircRNAs in Cancer Glycolysis
title_sort tip of the iceberg: roles of circrnas in cancer glycolysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039208/
https://www.ncbi.nlm.nih.gov/pubmed/33854335
http://dx.doi.org/10.2147/OTT.S297140
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