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Shed antigen-induced blocking effect on CAR-T cells targeting Glypican-3 in Hepatocellular Carcinoma

BACKGROUND: Glypican-3 (GPC3), a cell surface glycoprotein that is pathologically highly expressed in hepatocellular carcinoma (HCC), is an attractive target for immunotherapies, including chimeric antigen receptor (CAR) T cells. The serum GPC3 is frequently elevated in HCC patients due to the shedd...

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Detalles Bibliográficos
Autores principales:	Sun, Luan, Gao, Fang, Gao, Zhanhui, Ao, Lei, Li, Na, Ma, Sujuan, Jia, Meng, Li, Nan, Lu, Peihua, Sun, Beicheng, Ho, Mitchell, Jia, Shaochang, Ding, Tong, Gao, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039282/ https://www.ncbi.nlm.nih.gov/pubmed/33833049 http://dx.doi.org/10.1136/jitc-2020-001875

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