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Sarcopenic Obesity Is Significantly Associated With Coronary Artery Calcification
Background: An association between sarcopenic obesity and cardiovascular disease has been suggested. We investigated the relationship between sarcopenia and coronary atherosclerosis, taking into account the presence or absence of obesity in a health check-up population. Methods: Data were reviewed f...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039284/ https://www.ncbi.nlm.nih.gov/pubmed/33855037 http://dx.doi.org/10.3389/fmed.2021.651961 |
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author | Chung, Goh Eun Park, Hyo Eun Lee, Heesun Kim, Min Joo Choi, Su-Yeon Yim, Jeong Yoon Yoon, Ji Won |
author_facet | Chung, Goh Eun Park, Hyo Eun Lee, Heesun Kim, Min Joo Choi, Su-Yeon Yim, Jeong Yoon Yoon, Ji Won |
author_sort | Chung, Goh Eun |
collection | PubMed |
description | Background: An association between sarcopenic obesity and cardiovascular disease has been suggested. We investigated the relationship between sarcopenia and coronary atherosclerosis, taking into account the presence or absence of obesity in a health check-up population. Methods: Data were reviewed for subjects who underwent bioelectrical impedance analysis (BIA) and coronary calcium scoring (CAC) computed tomography between January 2017 and December 2018. Appendicular skeletal muscle mass (ASM) was assessed using BIA. Sarcopenia was defined as reduction of muscle mass and calculated as ASM% (ASM/body weight) more than two standard deviations below the sex-specific mean for healthy young adults. CAC scores were dichotomized as low (<100) or high (≥100). Results: Among 1,282 subjects (mean age, 58.1 years; 75.5% male), the prevalence of high CAC was 21%. When the study population was divided into four groups according to their obesity and sarcopenia status, the prevalence of high CAC in the sarcopenic-obesity (SO) group was significantly higher than in the other groups (40.7%, P < 0.001). After adjusting for age, sex, hypertension, diabetes, dyslipidemia, and creatinine, subjects with SO exhibited a significantly higher odds of a high CAC score, compared with the non-sarcopenic, non-obese group (odds ratio, 1.92; 95% confidence interval, 1.16–3.18, P = 0.011). Conclusion: SO was significantly associated with CAC, independent of known risk factors for coronary artery disease. These findings suggest that sarcopenia and obesity may potentiate each other to increase atherosclerotic burden in coronary arteries, which may eventually lead to adverse cardiovascular events. |
format | Online Article Text |
id | pubmed-8039284 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80392842021-04-13 Sarcopenic Obesity Is Significantly Associated With Coronary Artery Calcification Chung, Goh Eun Park, Hyo Eun Lee, Heesun Kim, Min Joo Choi, Su-Yeon Yim, Jeong Yoon Yoon, Ji Won Front Med (Lausanne) Medicine Background: An association between sarcopenic obesity and cardiovascular disease has been suggested. We investigated the relationship between sarcopenia and coronary atherosclerosis, taking into account the presence or absence of obesity in a health check-up population. Methods: Data were reviewed for subjects who underwent bioelectrical impedance analysis (BIA) and coronary calcium scoring (CAC) computed tomography between January 2017 and December 2018. Appendicular skeletal muscle mass (ASM) was assessed using BIA. Sarcopenia was defined as reduction of muscle mass and calculated as ASM% (ASM/body weight) more than two standard deviations below the sex-specific mean for healthy young adults. CAC scores were dichotomized as low (<100) or high (≥100). Results: Among 1,282 subjects (mean age, 58.1 years; 75.5% male), the prevalence of high CAC was 21%. When the study population was divided into four groups according to their obesity and sarcopenia status, the prevalence of high CAC in the sarcopenic-obesity (SO) group was significantly higher than in the other groups (40.7%, P < 0.001). After adjusting for age, sex, hypertension, diabetes, dyslipidemia, and creatinine, subjects with SO exhibited a significantly higher odds of a high CAC score, compared with the non-sarcopenic, non-obese group (odds ratio, 1.92; 95% confidence interval, 1.16–3.18, P = 0.011). Conclusion: SO was significantly associated with CAC, independent of known risk factors for coronary artery disease. These findings suggest that sarcopenia and obesity may potentiate each other to increase atherosclerotic burden in coronary arteries, which may eventually lead to adverse cardiovascular events. Frontiers Media S.A. 2021-03-29 /pmc/articles/PMC8039284/ /pubmed/33855037 http://dx.doi.org/10.3389/fmed.2021.651961 Text en Copyright © 2021 Chung, Park, Lee, Kim, Choi, Yim and Yoon. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Chung, Goh Eun Park, Hyo Eun Lee, Heesun Kim, Min Joo Choi, Su-Yeon Yim, Jeong Yoon Yoon, Ji Won Sarcopenic Obesity Is Significantly Associated With Coronary Artery Calcification |
title | Sarcopenic Obesity Is Significantly Associated With Coronary Artery Calcification |
title_full | Sarcopenic Obesity Is Significantly Associated With Coronary Artery Calcification |
title_fullStr | Sarcopenic Obesity Is Significantly Associated With Coronary Artery Calcification |
title_full_unstemmed | Sarcopenic Obesity Is Significantly Associated With Coronary Artery Calcification |
title_short | Sarcopenic Obesity Is Significantly Associated With Coronary Artery Calcification |
title_sort | sarcopenic obesity is significantly associated with coronary artery calcification |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039284/ https://www.ncbi.nlm.nih.gov/pubmed/33855037 http://dx.doi.org/10.3389/fmed.2021.651961 |
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