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Sarcopenic Obesity Is Significantly Associated With Coronary Artery Calcification

Background: An association between sarcopenic obesity and cardiovascular disease has been suggested. We investigated the relationship between sarcopenia and coronary atherosclerosis, taking into account the presence or absence of obesity in a health check-up population. Methods: Data were reviewed f...

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Autores principales: Chung, Goh Eun, Park, Hyo Eun, Lee, Heesun, Kim, Min Joo, Choi, Su-Yeon, Yim, Jeong Yoon, Yoon, Ji Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039284/
https://www.ncbi.nlm.nih.gov/pubmed/33855037
http://dx.doi.org/10.3389/fmed.2021.651961
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author Chung, Goh Eun
Park, Hyo Eun
Lee, Heesun
Kim, Min Joo
Choi, Su-Yeon
Yim, Jeong Yoon
Yoon, Ji Won
author_facet Chung, Goh Eun
Park, Hyo Eun
Lee, Heesun
Kim, Min Joo
Choi, Su-Yeon
Yim, Jeong Yoon
Yoon, Ji Won
author_sort Chung, Goh Eun
collection PubMed
description Background: An association between sarcopenic obesity and cardiovascular disease has been suggested. We investigated the relationship between sarcopenia and coronary atherosclerosis, taking into account the presence or absence of obesity in a health check-up population. Methods: Data were reviewed for subjects who underwent bioelectrical impedance analysis (BIA) and coronary calcium scoring (CAC) computed tomography between January 2017 and December 2018. Appendicular skeletal muscle mass (ASM) was assessed using BIA. Sarcopenia was defined as reduction of muscle mass and calculated as ASM% (ASM/body weight) more than two standard deviations below the sex-specific mean for healthy young adults. CAC scores were dichotomized as low (<100) or high (≥100). Results: Among 1,282 subjects (mean age, 58.1 years; 75.5% male), the prevalence of high CAC was 21%. When the study population was divided into four groups according to their obesity and sarcopenia status, the prevalence of high CAC in the sarcopenic-obesity (SO) group was significantly higher than in the other groups (40.7%, P < 0.001). After adjusting for age, sex, hypertension, diabetes, dyslipidemia, and creatinine, subjects with SO exhibited a significantly higher odds of a high CAC score, compared with the non-sarcopenic, non-obese group (odds ratio, 1.92; 95% confidence interval, 1.16–3.18, P = 0.011). Conclusion: SO was significantly associated with CAC, independent of known risk factors for coronary artery disease. These findings suggest that sarcopenia and obesity may potentiate each other to increase atherosclerotic burden in coronary arteries, which may eventually lead to adverse cardiovascular events.
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spelling pubmed-80392842021-04-13 Sarcopenic Obesity Is Significantly Associated With Coronary Artery Calcification Chung, Goh Eun Park, Hyo Eun Lee, Heesun Kim, Min Joo Choi, Su-Yeon Yim, Jeong Yoon Yoon, Ji Won Front Med (Lausanne) Medicine Background: An association between sarcopenic obesity and cardiovascular disease has been suggested. We investigated the relationship between sarcopenia and coronary atherosclerosis, taking into account the presence or absence of obesity in a health check-up population. Methods: Data were reviewed for subjects who underwent bioelectrical impedance analysis (BIA) and coronary calcium scoring (CAC) computed tomography between January 2017 and December 2018. Appendicular skeletal muscle mass (ASM) was assessed using BIA. Sarcopenia was defined as reduction of muscle mass and calculated as ASM% (ASM/body weight) more than two standard deviations below the sex-specific mean for healthy young adults. CAC scores were dichotomized as low (<100) or high (≥100). Results: Among 1,282 subjects (mean age, 58.1 years; 75.5% male), the prevalence of high CAC was 21%. When the study population was divided into four groups according to their obesity and sarcopenia status, the prevalence of high CAC in the sarcopenic-obesity (SO) group was significantly higher than in the other groups (40.7%, P < 0.001). After adjusting for age, sex, hypertension, diabetes, dyslipidemia, and creatinine, subjects with SO exhibited a significantly higher odds of a high CAC score, compared with the non-sarcopenic, non-obese group (odds ratio, 1.92; 95% confidence interval, 1.16–3.18, P = 0.011). Conclusion: SO was significantly associated with CAC, independent of known risk factors for coronary artery disease. These findings suggest that sarcopenia and obesity may potentiate each other to increase atherosclerotic burden in coronary arteries, which may eventually lead to adverse cardiovascular events. Frontiers Media S.A. 2021-03-29 /pmc/articles/PMC8039284/ /pubmed/33855037 http://dx.doi.org/10.3389/fmed.2021.651961 Text en Copyright © 2021 Chung, Park, Lee, Kim, Choi, Yim and Yoon. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Chung, Goh Eun
Park, Hyo Eun
Lee, Heesun
Kim, Min Joo
Choi, Su-Yeon
Yim, Jeong Yoon
Yoon, Ji Won
Sarcopenic Obesity Is Significantly Associated With Coronary Artery Calcification
title Sarcopenic Obesity Is Significantly Associated With Coronary Artery Calcification
title_full Sarcopenic Obesity Is Significantly Associated With Coronary Artery Calcification
title_fullStr Sarcopenic Obesity Is Significantly Associated With Coronary Artery Calcification
title_full_unstemmed Sarcopenic Obesity Is Significantly Associated With Coronary Artery Calcification
title_short Sarcopenic Obesity Is Significantly Associated With Coronary Artery Calcification
title_sort sarcopenic obesity is significantly associated with coronary artery calcification
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039284/
https://www.ncbi.nlm.nih.gov/pubmed/33855037
http://dx.doi.org/10.3389/fmed.2021.651961
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