Effects of Allicin on Late Sodium Current Caused by ΔKPQ-SCN5A Mutation in HEK293 Cells

AIM: The aim was to study the effect of Allitridum (Allicin) on the heterologous expression of the late sodium current on the ΔKPQ-SCN5A mutations in HEK293 cells, with a view to screening new drugs for the treatment of long QT syndrome type 3 (LQT3). METHODS AND RESULTS: The ΔKPQ-SCN5A plasmid was...

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Detalles Bibliográficos
Autores principales: Chen, Yating, Huang, Yun, Bai, Jing, Liu, Chuanbin, Ma, Shanshan, Li, Jiaxin, Lu, Xu, Fu, Zihao, Fang, Lihua, Li, Yang, Zhang, Jiancheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039306/
https://www.ncbi.nlm.nih.gov/pubmed/33854440
http://dx.doi.org/10.3389/fphys.2021.636485

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