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Complex Crystal Structure Determination and in vitro Anti–non–small Cell Lung Cancer Activity of Hsp90(N) Inhibitor SNX-2112

SNX-2112, as a promising anticancer lead compound targeting heat shock protein 90 (Hsp90), absence of complex crystal structure of Hsp90(N)-SNX-2112 hindered further structural optimization and understanding on molecular interaction mechanism. Herein, a high-resolution complex crystal structure of H...

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Detalles Bibliográficos
Autores principales:	Zhao, Dong, Xu, Yi-Ming, Cao, Lu-Qi, Yu, Feng, Zhou, Huan, Qin, Wei, Li, Hui-Jin, He, Chun-Xia, Xing, Lu, Zhou, Xin, Li, Peng-Quan, Jin, Xin, He, Yuan, He, Jian-Hua, Cao, Hui-Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039390/ https://www.ncbi.nlm.nih.gov/pubmed/33855025 http://dx.doi.org/10.3389/fcell.2021.650106

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