Loss of bound zinc facilitates amyloid fibril formation of leukocyte-cell-derived chemotaxin 2 (LECT2)

Aggregation of the circulating protein leukocyte-cell-derived chemotaxin 2 (LECT2) causes amyloidosis of LECT2 (ALECT2), one of the most prevalent forms of systemic amyloidosis affecting the kidney and liver. The I40V mutation is thought to be necessary but not sufficient for ALECT2, with a second,...

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Detalles Bibliográficos
Autores principales: Ha, Jeung-Hoi, Tu, Ho-Chou, Wilkens, Stephan, Loh, Stewart N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Accelerated Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039541/
https://www.ncbi.nlm.nih.gov/pubmed/33617884
http://dx.doi.org/10.1016/j.jbc.2021.100446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039541/
https://www.ncbi.nlm.nih.gov/pubmed/33617884
http://dx.doi.org/10.1016/j.jbc.2021.100446

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