Identification of MKRN1 as a second E3 ligase for Eag1 potassium channels reveals regulation via differential degradation

Mutations in the human gene encoding the neuron-specific Eag1 voltage-gated K(+) channel are associated with neurodevelopmental diseases, indicating an important role of Eag1 during brain development. A disease-causing Eag1 mutation is linked to decreased protein stability that involves enhanced pro...

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Detalles Bibliográficos
Autores principales: Fang, Ya-Ching, Fu, Ssu-Ju, Hsu, Po-Hao, Chang, Pei-Tzu, Huang, Jing-Jia, Chiu, Yi-Chih, Liao, Yi-Fan, Jow, Guey-Mei, Tang, Chih-Yung, Jeng, Chung-Jiuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039722/
https://www.ncbi.nlm.nih.gov/pubmed/33647316
http://dx.doi.org/10.1016/j.jbc.2021.100484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039722/
https://www.ncbi.nlm.nih.gov/pubmed/33647316
http://dx.doi.org/10.1016/j.jbc.2021.100484

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