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Identification of MKRN1 as a second E3 ligase for Eag1 potassium channels reveals regulation via differential degradation
Mutations in the human gene encoding the neuron-specific Eag1 voltage-gated K(+) channel are associated with neurodevelopmental diseases, indicating an important role of Eag1 during brain development. A disease-causing Eag1 mutation is linked to decreased protein stability that involves enhanced pro...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039722/ https://www.ncbi.nlm.nih.gov/pubmed/33647316 http://dx.doi.org/10.1016/j.jbc.2021.100484 |