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Short-term developmental outcomes in neonates born to mothers with COVID-19 from Wuhan, China

BACKGROUND: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging disease. The consequences of SARS-CoV-2 exposure in infants remain unknown. Therefore, this study aims to investigate whether neonates born to mothers with COVID-19 h...

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Autores principales: Zeng, Ling-Kong, Zhu, Hua-Ping, Xiao, Tian-Tian, Peng, Si-Cong, Yuan, Wen-Hao, Shao, Jian-Bo, Wang, Lai-Shuan, Xiao, Fei-Fan, Xia, Shi-Wen, Lee, Shoo K., Yan, Kai, Zhou, Wen-Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039812/
https://www.ncbi.nlm.nih.gov/pubmed/33844176
http://dx.doi.org/10.1007/s12519-021-00426-z
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author Zeng, Ling-Kong
Zhu, Hua-Ping
Xiao, Tian-Tian
Peng, Si-Cong
Yuan, Wen-Hao
Shao, Jian-Bo
Wang, Lai-Shuan
Xiao, Fei-Fan
Xia, Shi-Wen
Lee, Shoo K.
Yan, Kai
Zhou, Wen-Hao
author_facet Zeng, Ling-Kong
Zhu, Hua-Ping
Xiao, Tian-Tian
Peng, Si-Cong
Yuan, Wen-Hao
Shao, Jian-Bo
Wang, Lai-Shuan
Xiao, Fei-Fan
Xia, Shi-Wen
Lee, Shoo K.
Yan, Kai
Zhou, Wen-Hao
author_sort Zeng, Ling-Kong
collection PubMed
description BACKGROUND: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging disease. The consequences of SARS-CoV-2 exposure in infants remain unknown. Therefore, this study aims to investigate whether neonates born to mothers with COVID-19 have adverse brain development. METHODS: This multicenter observational study was conducted at two designated maternal and children’s hospitals in Hubei Province, mainland China from February 1, 2020 to May 15, 2020. Neonates born to mothers with COVID-19 were enrolled. Brain magnetic resonance imaging (MRI) findings, and volumes of grey and white matters, and physical growth parameters were observed at 44 weeks corrected gestational age. RESULTS: Of 72 neonates born to mothers with COVID-19, 8 (11%) were diagnosed with COVID-19, 8 (11%) were critically ill, and no deaths were reported. Among the eight neonates that underwent brain MRI at corrected gestational age of 44 weeks, five neonates were diagnosed with COVID-19. Among these five neonates, three presented abnormal MRI findings including abnormal signal in white matter and delayed myelination in newborn 2, delayed myelination and brain dysplasia in newborn 3, and abnormal signal in the bilateral periventricular in newborn 5. The other three neonates without COVID-19 presented no significantly changes of brain MRI findings and the volumes of grey matter and white matter compared to those of healthy newborns at the equivalent age (P > 0.05). Physical growth parameters for weight, length, and head circumference at gestational age of 44 weeks were all above the 3rd percentile for all neonates. CONCLUSIONS: Some of the neonates born to mothers with COVID-19 had abnormal brain MRI findings but these neonates did not appear to have poor physical growth. These findings may provide the information on the follow-up schedule on the neonates exposed to SARS-CoV-2, but further study is required to evaluate the association between the abnormal MRI findings and the exposure to SARS-CoV-2. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12519-021-00426-z.
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spelling pubmed-80398122021-04-12 Short-term developmental outcomes in neonates born to mothers with COVID-19 from Wuhan, China Zeng, Ling-Kong Zhu, Hua-Ping Xiao, Tian-Tian Peng, Si-Cong Yuan, Wen-Hao Shao, Jian-Bo Wang, Lai-Shuan Xiao, Fei-Fan Xia, Shi-Wen Lee, Shoo K. Yan, Kai Zhou, Wen-Hao World J Pediatr Original Article BACKGROUND: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging disease. The consequences of SARS-CoV-2 exposure in infants remain unknown. Therefore, this study aims to investigate whether neonates born to mothers with COVID-19 have adverse brain development. METHODS: This multicenter observational study was conducted at two designated maternal and children’s hospitals in Hubei Province, mainland China from February 1, 2020 to May 15, 2020. Neonates born to mothers with COVID-19 were enrolled. Brain magnetic resonance imaging (MRI) findings, and volumes of grey and white matters, and physical growth parameters were observed at 44 weeks corrected gestational age. RESULTS: Of 72 neonates born to mothers with COVID-19, 8 (11%) were diagnosed with COVID-19, 8 (11%) were critically ill, and no deaths were reported. Among the eight neonates that underwent brain MRI at corrected gestational age of 44 weeks, five neonates were diagnosed with COVID-19. Among these five neonates, three presented abnormal MRI findings including abnormal signal in white matter and delayed myelination in newborn 2, delayed myelination and brain dysplasia in newborn 3, and abnormal signal in the bilateral periventricular in newborn 5. The other three neonates without COVID-19 presented no significantly changes of brain MRI findings and the volumes of grey matter and white matter compared to those of healthy newborns at the equivalent age (P > 0.05). Physical growth parameters for weight, length, and head circumference at gestational age of 44 weeks were all above the 3rd percentile for all neonates. CONCLUSIONS: Some of the neonates born to mothers with COVID-19 had abnormal brain MRI findings but these neonates did not appear to have poor physical growth. These findings may provide the information on the follow-up schedule on the neonates exposed to SARS-CoV-2, but further study is required to evaluate the association between the abnormal MRI findings and the exposure to SARS-CoV-2. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12519-021-00426-z. Springer Singapore 2021-04-12 2021 /pmc/articles/PMC8039812/ /pubmed/33844176 http://dx.doi.org/10.1007/s12519-021-00426-z Text en © Children's Hospital, Zhejiang University School of Medicine 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Article
Zeng, Ling-Kong
Zhu, Hua-Ping
Xiao, Tian-Tian
Peng, Si-Cong
Yuan, Wen-Hao
Shao, Jian-Bo
Wang, Lai-Shuan
Xiao, Fei-Fan
Xia, Shi-Wen
Lee, Shoo K.
Yan, Kai
Zhou, Wen-Hao
Short-term developmental outcomes in neonates born to mothers with COVID-19 from Wuhan, China
title Short-term developmental outcomes in neonates born to mothers with COVID-19 from Wuhan, China
title_full Short-term developmental outcomes in neonates born to mothers with COVID-19 from Wuhan, China
title_fullStr Short-term developmental outcomes in neonates born to mothers with COVID-19 from Wuhan, China
title_full_unstemmed Short-term developmental outcomes in neonates born to mothers with COVID-19 from Wuhan, China
title_short Short-term developmental outcomes in neonates born to mothers with COVID-19 from Wuhan, China
title_sort short-term developmental outcomes in neonates born to mothers with covid-19 from wuhan, china
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039812/
https://www.ncbi.nlm.nih.gov/pubmed/33844176
http://dx.doi.org/10.1007/s12519-021-00426-z
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