Cargando…

Characterization of drug-induced human mitochondrial ADP/ATP carrier inhibition

An increasing number of commonly prescribed drugs are known to interfere with mitochondrial function, causing cellular toxicity, but the underlying mechanisms are largely unknown. Although often not considered, mitochondrial transport proteins form a significant class of potential mitochondrial off-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jaiquel Baron, Stephany, King, Martin S., Kunji, Edmund R.S., Schirris, Tom J.J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039944/ https://www.ncbi.nlm.nih.gov/pubmed/33859735 http://dx.doi.org/10.7150/thno.54936

Ejemplares similares

Human mitochondrial ADP/ATP carrier SLC25A4 operates with a ping‐pong kinetic mechanism
por: Cimadamore‐Werthein, Camila, et al.
Publicado: (2023)

Structural changes in the transport cycle of the mitochondrial ADP/ATP carrier
por: Ruprecht, Jonathan J, et al.
Publicado: (2019)

The mitochondrial ADP/ATP carrier exists and functions as a monomer
por: Kunji, Edmund R.S., et al.
Publicado: (2020)

Modelling the free energy profile of the mitochondrial ADP/ATP carrier
por: Springett, Roger, et al.
Publicado: (2017)

The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier
por: Ruprecht, Jonathan J., et al.
Publicado: (2019)

Mitochondrial ADP/ATP Carrier in Dodecylphosphocholine Binds Cardiolipins with Non-native Affinity
por: Dehez, François, et al.
Publicado: (2017)

Cardiolipin dynamics and binding to conserved residues in the mitochondrial ADP/ATP carrier
por: Duncan, Anna L., et al.
Publicado: (2018)

Formation of a cytoplasmic salt bridge network in the matrix state is a fundamental step in the transport mechanism of the mitochondrial ADP/ATP carrier
por: King, Martin S., et al.
Publicado: (2016)

Key features of inhibitor binding to the human mitochondrial pyruvate carrier hetero-dimer
por: Tavoulari, Sotiria, et al.
Publicado: (2022)

Calcium‐regulated mitochondrial ATP‐Mg/P(i) carriers evolved from a fusion of an EF‐hand regulatory domain with a mitochondrial ADP/ATP carrier‐like domain
por: Harborne, Steven P. D., et al.
Publicado: (2018)

Substrate binding in the mitochondrial ADP/ATP carrier is a step-wise process guiding the structural changes in the transport cycle
por: Mavridou, Vasiliki, et al.
Publicado: (2022)

Corrigendum to “Formation of a cytoplasmic salt bridge network in the matrix state is a fundamental step in the transport mechanism of the mitochondrial ADP/ATP carrier” [Biochim. Biophys. Acta 1857 (2016) 14–22]
por: King, Martin S., et al.
Publicado: (2016)

Calcium-induced conformational changes in the regulatory domain of the human mitochondrial ATP-Mg/Pi carrier
por: Harborne, Steven P.D., et al.
Publicado: (2015)

Metabolic impact of genetic and chemical ADP/ATP carrier inhibition in renal proximal tubule epithelial cells
por: Hoogstraten, Charlotte A., et al.
Publicado: (2023)

The SLC25 Mitochondrial Carrier Family: Structure and Mechanism
por: Ruprecht, Jonathan J., et al.
Publicado: (2020)

Mitochondrial ADP/ATP exchange inhibition: a novel off-target mechanism underlying ibipinabant-induced myotoxicity
por: Schirris, Tom J. J., et al.
Publicado: (2015)

A Single Cysteine Residue in the Translocation Pathway of the Mitosomal ADP/ATP Carrier from Cryptosporidium parvum Confers a Broad Nucleotide Specificity
por: King, Martin S., et al.
Publicado: (2020)

The SLC25 Carrier Family: Important Transport Proteins in Mitochondrial Physiology and Pathology
por: Kunji, Edmund R.S., et al.
Publicado: (2020)

H(+) Transport is an Integral Function of the Mitochondrial ADP/ATP Carrier
por: Bertholet, Ambre M., et al.
Publicado: (2019)

Mechanistic insights into multiple-step transport of mitochondrial ADP/ATP carrier
por: Yao, Shihao, et al.
Publicado: (2022)

Mitochondrial ADP/ATP Carrier 1 Is Important for the Growth of Toxoplasma Tachyzoites
por: Qian, Jiahui, et al.
Publicado: (2023)

Pathogenic variants of the mitochondrial aspartate/glutamate carrier causing citrin deficiency
por: Tavoulari, Sotiria, et al.
Publicado: (2022)

Calcium regulation of the human mitochondrial ATP-Mg/Pi carrier SLC25A24 uses a locking pin mechanism
por: Harborne, Steven P. D., et al.
Publicado: (2017)

The molecular features of uncoupling protein 1 support a conventional mitochondrial carrier-like mechanism
por: Crichton, Paul G., et al.
Publicado: (2017)

The mitochondrial dicarboxylate and 2-oxoglutarate carriers do not transport glutathione
por: Booty, Lee M., et al.
Publicado: (2015)

Cardiolipin defines the interactome of the major ADP/ATP carrier protein of the mitochondrial inner membrane
por: Claypool, Steven M., et al.
Publicado: (2008)

Cardiolipin defines the interactome of the major ADP/ATP carrier protein of the mitochondrial inner membrane
por: Claypool, Steven M., et al.
Publicado: (2012)

The free-living flagellate Paratrimastix pyriformis uses a distinct mitochondrial carrier to balance adenine nucleotide pools
por: Zítek, Justyna, et al.
Publicado: (2023)

Cardiolipin, conformation, and respiratory complex-dependent oligomerization of the major mitochondrial ADP/ATP carrier in yeast
por: Senoo, N., et al.
Publicado: (2020)

The effects of cardiolipin on the structural dynamics of the mitochondrial ADP/ATP carrier in its cytosol-open state
por: Yi, Qiuzi, et al.
Publicado: (2022)

The yeast mitochondrial pyruvate carrier is a hetero‐dimer in its functional state
por: Tavoulari, Sotiria, et al.
Publicado: (2019)

Investigating the Broad Matrix-Gate Network in the Mitochondrial ADP/ATP Carrier through Molecular Dynamics Simulations
por: Yao, Shihao, et al.
Publicado: (2022)

Import of ADP/ATP carrier into mitochondria: two receptors act in parallel
Publicado: (1990)

Function-Related Asymmetry of the Interactions between Matrix Loops and Conserved Sequence Motifs in the Mitochondrial ADP/ATP Carrier
por: Yi, Qiuzi, et al.
Publicado: (2022)

Conserved cardiolipin-mitochondrial ADP/ATP carrier interactions assume distinct structural and functional roles that are clinically relevant
por: Senoo, Nanami, et al.
Publicado: (2023)

Calcium-induced conformational changes of the regulatory domain of human mitochondrial aspartate/glutamate carriers
por: Thangaratnarajah, Chancievan, et al.
Publicado: (2014)

Trends in Thermostability Provide Information on the Nature of Substrate, Inhibitor, and Lipid Interactions with Mitochondrial Carriers
por: Crichton, Paul G., et al.
Publicado: (2015)

ATP/ADP biosensor organoids for drug nephrotoxicity assessment
por: Susa, Koichiro, et al.
Publicado: (2023)

Exome sequencing identifies a disease variant of the mitochondrial ATP‐Mg/Pi carrier SLC25A25 in two families with kidney stones
por: Jabalameli, M. Reza, et al.
Publicado: (2021)

Differential Expression of ADP/ATP Carriers as a Biomarker of Metabolic Remodeling and Survival in Kidney Cancers
por: Trisolini, Lucia, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_3upls744b9rldm76gvnmnuvv5f