A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models

Intracellular accumulation of tau is a hallmark pathology in Alzheimer disease (AD) and the related tauopathies, thus targeting tau could be promising for drug development. Proteolysis Targeting Chimera (PROTAC) is a novel drug discovery strategy for selective protein degradation from within cells....

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Detalles Bibliográficos
Autores principales: Wang, Weijin, Zhou, Qiuzhi, Jiang, Tao, Li, Shihong, Ye, Jinwang, Zheng, Jie, Wang, Xin, Liu, Yanchao, Deng, Minmin, Ke, Dan, Wang, Qun, Wang, Yipeng, Wang, Jian-Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039949/
https://www.ncbi.nlm.nih.gov/pubmed/33859747
http://dx.doi.org/10.7150/thno.55680

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