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Malfunction of outer retinal barrier and choroid in the occurrence and progression of diabetic macular edema

Diabetic macular edema (DME) is the most common cause of vision loss in diabetic retinopathy, affecting 1 in 15 patients with diabetes mellitus (DM). The disruption of the inner blood-retina barrier (BRB) has been largely investigated and attributed the primary role in the pathogenesis and progressi...

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Autores principales: Ţălu, Ştefan, Nicoara, Simona Delia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040083/
https://www.ncbi.nlm.nih.gov/pubmed/33889289
http://dx.doi.org/10.4239/wjd.v12.i4.437
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author Ţălu, Ştefan
Nicoara, Simona Delia
author_facet Ţălu, Ştefan
Nicoara, Simona Delia
author_sort Ţălu, Ştefan
collection PubMed
description Diabetic macular edema (DME) is the most common cause of vision loss in diabetic retinopathy, affecting 1 in 15 patients with diabetes mellitus (DM). The disruption of the inner blood-retina barrier (BRB) has been largely investigated and attributed the primary role in the pathogenesis and progression in DME, but there is increasing evidence regarding the role of outer BRB, separating the RPE from the underlying choriocapillaris, in the occurrence and evolution of DME. The development of novel imaging technologies has led to major improvement in the field of in vivo structural analysis of the macula allowing us to delve deeper into the pathogenesis of DME and expanding our vision regarding this condition. In this review we gathered the results of studies that investigated specific outer BRB optical coherence tomography parameters in patients with DM with the aim to outline the current status of its role in the pathogenesis and progression of DME and identify new research pathways contributing to the advancement of knowledge in the understanding of this condition.
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spelling pubmed-80400832021-04-21 Malfunction of outer retinal barrier and choroid in the occurrence and progression of diabetic macular edema Ţălu, Ştefan Nicoara, Simona Delia World J Diabetes Minireviews Diabetic macular edema (DME) is the most common cause of vision loss in diabetic retinopathy, affecting 1 in 15 patients with diabetes mellitus (DM). The disruption of the inner blood-retina barrier (BRB) has been largely investigated and attributed the primary role in the pathogenesis and progression in DME, but there is increasing evidence regarding the role of outer BRB, separating the RPE from the underlying choriocapillaris, in the occurrence and evolution of DME. The development of novel imaging technologies has led to major improvement in the field of in vivo structural analysis of the macula allowing us to delve deeper into the pathogenesis of DME and expanding our vision regarding this condition. In this review we gathered the results of studies that investigated specific outer BRB optical coherence tomography parameters in patients with DM with the aim to outline the current status of its role in the pathogenesis and progression of DME and identify new research pathways contributing to the advancement of knowledge in the understanding of this condition. Baishideng Publishing Group Inc 2021-04-15 2021-04-15 /pmc/articles/PMC8040083/ /pubmed/33889289 http://dx.doi.org/10.4239/wjd.v12.i4.437 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Minireviews
Ţălu, Ştefan
Nicoara, Simona Delia
Malfunction of outer retinal barrier and choroid in the occurrence and progression of diabetic macular edema
title Malfunction of outer retinal barrier and choroid in the occurrence and progression of diabetic macular edema
title_full Malfunction of outer retinal barrier and choroid in the occurrence and progression of diabetic macular edema
title_fullStr Malfunction of outer retinal barrier and choroid in the occurrence and progression of diabetic macular edema
title_full_unstemmed Malfunction of outer retinal barrier and choroid in the occurrence and progression of diabetic macular edema
title_short Malfunction of outer retinal barrier and choroid in the occurrence and progression of diabetic macular edema
title_sort malfunction of outer retinal barrier and choroid in the occurrence and progression of diabetic macular edema
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040083/
https://www.ncbi.nlm.nih.gov/pubmed/33889289
http://dx.doi.org/10.4239/wjd.v12.i4.437
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