Advancing peptide siRNA-carrier designs through L/D-amino acid stereochemical modifications to enhance gene silencing

The 599 peptide has been previously shown to effectively deliver small interfering RNAs (siRNAs) to cancer cells, inducing targeted-oncogene silencing, with a consequent inhibition of tumor growth. Although effective, this study was undertaken to advance the 599 peptide siRNA-carrier design through...

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Detalles Bibliográficos
Autores principales: Holjencin, Charles E., Feinberg, Colton R., Hedrick, Travis, Halsey, Gregory, Williams, Robert D., Patel, Priya V., Biles, Evan, Cummings, James C., Wagner, Chance, Vyavahare, Naren, Jakymiw, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040110/
https://www.ncbi.nlm.nih.gov/pubmed/33868789
http://dx.doi.org/10.1016/j.omtn.2021.03.013

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