Potential capacity of interferon-α to eliminate covalently closed circular DNA (cccDNA) in hepatocytes infected with hepatitis B virus

Interferon-alpha (IFN-α) and nucleot(s)ide analogs (NAs) are first-line drugs for the treatment of chronic hepatitis B virus (HBV) infections. Generally, NAs target the reverse transcription of HBV pregenomic RNA, but they cannot eliminate covalently-closed-circular DNA (cccDNA). Although effective...

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Detalles Bibliográficos
Autores principales: Wang, Gang, Guan, Jun, Khan, Nazif U., Li, Guojun, Shao, Junwei, Zhou, Qihui, Xu, Lichen, Huang, Chunhong, Deng, Jingwen, Zhu, Haihong, Chen, Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040234/
https://www.ncbi.nlm.nih.gov/pubmed/33845868
http://dx.doi.org/10.1186/s13099-021-00421-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040234/
https://www.ncbi.nlm.nih.gov/pubmed/33845868
http://dx.doi.org/10.1186/s13099-021-00421-9

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