Cargando…

Potential capacity of interferon-α to eliminate covalently closed circular DNA (cccDNA) in hepatocytes infected with hepatitis B virus

Interferon-alpha (IFN-α) and nucleot(s)ide analogs (NAs) are first-line drugs for the treatment of chronic hepatitis B virus (HBV) infections. Generally, NAs target the reverse transcription of HBV pregenomic RNA, but they cannot eliminate covalently-closed-circular DNA (cccDNA). Although effective...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Gang, Guan, Jun, Khan, Nazif U., Li, Guojun, Shao, Junwei, Zhou, Qihui, Xu, Lichen, Huang, Chunhong, Deng, Jingwen, Zhu, Haihong, Chen, Zhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040234/ https://www.ncbi.nlm.nih.gov/pubmed/33845868 http://dx.doi.org/10.1186/s13099-021-00421-9

Ejemplares similares

Minicircle HBV cccDNA with a Gaussia luciferase reporter for investigating HBV cccDNA biology and developing cccDNA-targeting drugs
por: Li, Feng, et al.
Publicado: (2016)

The Role of cccDNA in HBV Maintenance
por: Allweiss, Lena, et al.
Publicado: (2017)

Gene Therapy for Chronic HBV—Can We Eliminate cccDNA?
por: Bloom, Kristie, et al.
Publicado: (2018)

Mapping the Interactions of HBV cccDNA with Host Factors
por: Mohd-Ismail, Nur K., et al.
Publicado: (2019)

Mechanism of Hepatitis B Virus cccDNA Formation
por: Wei, Lei, et al.
Publicado: (2021)

Gene Editing Technologies to Target HBV cccDNA
por: Martinez, Maria Guadalupe, et al.
Publicado: (2022)

Alpha-Interferon Suppresses Hepadnavirus Transcription by Altering Epigenetic Modification of cccDNA Minichromosomes
por: Liu, Fei, et al.
Publicado: (2013)

Baseline value of intrahepatic HBV DNA over cccDNA predicts patient’s response to interferon therapy
por: Mu, Di, et al.
Publicado: (2017)

Targeting Viral cccDNA for Cure of Chronic Hepatitis B
por: Ligat, Gaëtan, et al.
Publicado: (2020)

HBV cccDNA and Its Potential as a Therapeutic Target
por: Zhu, Anjing, et al.
Publicado: (2019)

HBV cccDNA: The Stumbling Block for Treatment of HBV Infection
por: Liu, Shousheng, et al.
Publicado: (2019)

Cell-based cccDNA reporter assay combined with functional genomics identifies YBX1 as HBV cccDNA host factor and antiviral candidate target
por: Verrier, Eloi R, et al.
Publicado: (2023)

Interferon‐induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20
por: Stadler, Daniela, et al.
Publicado: (2021)

Estimating hepatitis B virus cccDNA persistence in chronic infection(†)
por: Lythgoe, Katrina A, et al.
Publicado: (2020)

IFN-α confers epigenetic regulation of HBV cccDNA minichromosome by modulating GCN5-mediated succinylation of histone H3K79 to clear HBV cccDNA
por: Yuan, Ying, et al.
Publicado: (2020)

Dynamics of HBV cccDNA expression and transcription in different cell growth phase
por: Chong, Chin-Liew, et al.
Publicado: (2011)

Complete Spectrum of CRISPR/Cas9-induced Mutations on HBV cccDNA
por: Seeger, Christoph, et al.
Publicado: (2016)

Flap endonuclease 1 is involved in cccDNA formation in the hepatitis B virus
por: Kitamura, Kouichi, et al.
Publicado: (2018)

cccDNA Maintenance in Chronic Hepatitis B – Targeting the Matrix of Viral Replication
por: Dandri, Maura, et al.
Publicado: (2020)

Characterization of the Host Factors Required for Hepadnavirus Covalently Closed Circular (ccc) DNA Formation
por: Guo, Haitao, et al.
Publicado: (2012)

Targeting the hepatitis B cccDNA with a sequence-specific ARCUS nuclease to eliminate hepatitis B virus in vivo
por: Gorsuch, Cassandra L., et al.
Publicado: (2022)

The recombined cccDNA produced using minicircle technology mimicked HBV genome in structure and function closely
por: Guo, Xiaoyan, et al.
Publicado: (2016)

Reduced HBV cccDNA and HBsAg in HBV-associated hepatocellular carcinoma tissues
por: Tantiwetrueangdet, Anchalee, et al.
Publicado: (2018)

HAT1 signaling confers to assembly and epigenetic regulation of HBV cccDNA minichromosome
por: Yang, Guang, et al.
Publicado: (2019)

Super-Resolution Microscopy Analysis of Hepatitis B Viral cccDNA and Host Factors
por: Doan, Phuong Thi Bich, et al.
Publicado: (2023)

A Role for the Host DNA Damage Response in Hepatitis B Virus cccDNA Formation—and Beyond?
por: Schreiner, Sabrina, et al.
Publicado: (2017)

IL6 Inhibits HBV Transcription by Targeting the Epigenetic Control of the Nuclear cccDNA Minichromosome
por: Palumbo, Gianna Aurora, et al.
Publicado: (2015)

Inhibition of HBV Transcription From cccDNA With Nitazoxanide by Targeting the HBx–DDB1 Interaction
por: Sekiba, Kazuma, et al.
Publicado: (2018)

Hepatitis B virus cccDNA is formed through distinct repair processes of each strand
por: Wei, Lei, et al.
Publicado: (2021)

Core components of DNA lagging strand synthesis machinery are essential for hepatitis B virus cccDNA formation
por: Wei, Lei, et al.
Publicado: (2020)

Serum HBV RNA correlated with intrahepatic cccDNA more strongly than other HBV markers during peg-interferon treatment
por: Wang, Xiaomei, et al.
Publicado: (2021)

cccDNA Surrogate MC-HBV–Based Screen Identifies Cohesin Complex as a Novel HBV Restriction Factor
por: Wu, Zhuanchang, et al.
Publicado: (2022)

Correction: IL6 Inhibits HBV Transcription by Targeting the Epigenetic Control of the Nuclear cccDNA Minichromosome
por: Palumbo, Gianna Aurora, et al.
Publicado: (2015)

Curcumin inhibits hepatitis B virus infection by down-regulating cccDNA-bound histone acetylation
por: Wei, Zhi-Qiang, et al.
Publicado: (2017)

A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis
por: Wing, Peter AC, et al.
Publicado: (2019)

De novo synthesis of hepatitis B virus nucleocapsids is dispensable for the maintenance and transcriptional regulation of cccDNA
por: Tu, Thomas, et al.
Publicado: (2020)

Analysis of HBsAg Immunocomplexes and cccDNA Activity During and Persisting After NAP‐Based Therapy
por: Bazinet, Michel, et al.
Publicado: (2021)

Droplet digital PCR assay provides intrahepatic HBV cccDNA quantification tool for clinical application
por: Hayashi, Sanae, et al.
Publicado: (2022)

Early Steps of Hepatitis B Life Cycle: From Capsid Nuclear Import to cccDNA Formation
por: Diogo Dias, João, et al.
Publicado: (2021)

Reduction in Intrahepatic cccDNA and Integration of HBV in Chronic Hepatitis B Patients with a Functional Cure
por: Gan, Weiqiang, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_h0kgi76b7i6rgjimbjh18pbulp