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Photoacoustic flow velocity imaging based on complex field decorrelation

Photoacoustic (PA) imaging can be used to monitor flowing blood inside the microvascular and capillary bed. Ultrasound speckle decorrelation based velocimetry imaging was previously shown to accurately estimate blood flow velocity in mouse brain (micro-)vasculature. Translating this method to photoa...

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Autores principales: Pakdaman Zangabad, Reza, Iskander-Rizk, Sophinese, van der Meulen, Pim, Meijlink, Bram, Kooiman, Klazina, Wang, Tianshi, van der Steen, Antonius F.W., van Soest, Gijs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040274/
https://www.ncbi.nlm.nih.gov/pubmed/33868919
http://dx.doi.org/10.1016/j.pacs.2021.100256
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author Pakdaman Zangabad, Reza
Iskander-Rizk, Sophinese
van der Meulen, Pim
Meijlink, Bram
Kooiman, Klazina
Wang, Tianshi
van der Steen, Antonius F.W.
van Soest, Gijs
author_facet Pakdaman Zangabad, Reza
Iskander-Rizk, Sophinese
van der Meulen, Pim
Meijlink, Bram
Kooiman, Klazina
Wang, Tianshi
van der Steen, Antonius F.W.
van Soest, Gijs
author_sort Pakdaman Zangabad, Reza
collection PubMed
description Photoacoustic (PA) imaging can be used to monitor flowing blood inside the microvascular and capillary bed. Ultrasound speckle decorrelation based velocimetry imaging was previously shown to accurately estimate blood flow velocity in mouse brain (micro-)vasculature. Translating this method to photoacoustic imaging will allow simultaneous imaging of flow velocity and extracting functional parameters like blood oxygenation. In this study, we use a pulsed laser diode and a quantitative method based on normalized first order field autocorrelation function of PA field fluctuations to estimate flow velocities in an ink tube phantom and in the microvasculature of the chorioallantoic membrane of a chicken embryo. We demonstrate how the decorrelation time of signals acquired over frames are related to the flow speed and show that the PA flow analysis based on this approach is an angle independent flow velocity imaging method.
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spelling pubmed-80402742021-04-15 Photoacoustic flow velocity imaging based on complex field decorrelation Pakdaman Zangabad, Reza Iskander-Rizk, Sophinese van der Meulen, Pim Meijlink, Bram Kooiman, Klazina Wang, Tianshi van der Steen, Antonius F.W. van Soest, Gijs Photoacoustics Research Article Photoacoustic (PA) imaging can be used to monitor flowing blood inside the microvascular and capillary bed. Ultrasound speckle decorrelation based velocimetry imaging was previously shown to accurately estimate blood flow velocity in mouse brain (micro-)vasculature. Translating this method to photoacoustic imaging will allow simultaneous imaging of flow velocity and extracting functional parameters like blood oxygenation. In this study, we use a pulsed laser diode and a quantitative method based on normalized first order field autocorrelation function of PA field fluctuations to estimate flow velocities in an ink tube phantom and in the microvasculature of the chorioallantoic membrane of a chicken embryo. We demonstrate how the decorrelation time of signals acquired over frames are related to the flow speed and show that the PA flow analysis based on this approach is an angle independent flow velocity imaging method. Elsevier 2021-03-09 /pmc/articles/PMC8040274/ /pubmed/33868919 http://dx.doi.org/10.1016/j.pacs.2021.100256 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Pakdaman Zangabad, Reza
Iskander-Rizk, Sophinese
van der Meulen, Pim
Meijlink, Bram
Kooiman, Klazina
Wang, Tianshi
van der Steen, Antonius F.W.
van Soest, Gijs
Photoacoustic flow velocity imaging based on complex field decorrelation
title Photoacoustic flow velocity imaging based on complex field decorrelation
title_full Photoacoustic flow velocity imaging based on complex field decorrelation
title_fullStr Photoacoustic flow velocity imaging based on complex field decorrelation
title_full_unstemmed Photoacoustic flow velocity imaging based on complex field decorrelation
title_short Photoacoustic flow velocity imaging based on complex field decorrelation
title_sort photoacoustic flow velocity imaging based on complex field decorrelation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040274/
https://www.ncbi.nlm.nih.gov/pubmed/33868919
http://dx.doi.org/10.1016/j.pacs.2021.100256
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