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Phylobioactive hotspots in plant resources used to treat Chagas disease

Globally, more than six million people are infected with Trypanosoma cruzi, the causative protozoan parasite of the vector-borne Chagas disease (CD). We conducted a cross-sectional ethnopharmacological field study in Bolivia among different ethnic groups where CD is hyperendemic. A total of 775 extr...

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Autores principales: Salm, Andrea, Krishnan, Sandhya R., Collu, Marta, Danton, Ombeline, Hamburger, Matthias, Leonti, Marco, Almanza, Giovanna, Gertsch, Jürg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040286/
https://www.ncbi.nlm.nih.gov/pubmed/33870129
http://dx.doi.org/10.1016/j.isci.2021.102310
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author Salm, Andrea
Krishnan, Sandhya R.
Collu, Marta
Danton, Ombeline
Hamburger, Matthias
Leonti, Marco
Almanza, Giovanna
Gertsch, Jürg
author_facet Salm, Andrea
Krishnan, Sandhya R.
Collu, Marta
Danton, Ombeline
Hamburger, Matthias
Leonti, Marco
Almanza, Giovanna
Gertsch, Jürg
author_sort Salm, Andrea
collection PubMed
description Globally, more than six million people are infected with Trypanosoma cruzi, the causative protozoan parasite of the vector-borne Chagas disease (CD). We conducted a cross-sectional ethnopharmacological field study in Bolivia among different ethnic groups where CD is hyperendemic. A total of 775 extracts of botanical drugs used in Bolivia in the context of CD and botanical drugs from unrelated indications from the Mediterranean De Materia Medica compiled by Dioscorides two thousand years ago were profiled in a multidimensional assay uncovering different antichagasic natural product classes. Intriguingly, the phylobioactive anthraquinone hotspot matched the antichagasic activity of Senna chloroclada, the taxon with the strongest ethnomedical consensus for treating CD among the Izoceño-Guaraní. Testing common 9,10-anthracenedione derivatives in T. cruzi cellular infection assays demarcates hydroxyanthraquinone as a potential antichagasic lead scaffold. Our study systematically uncovers in vitro antichagasic phylogenetic hotspots in the plant kingdom as a potential resource for drug discovery based on ethnopharmacological hypotheses.
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spelling pubmed-80402862021-04-15 Phylobioactive hotspots in plant resources used to treat Chagas disease Salm, Andrea Krishnan, Sandhya R. Collu, Marta Danton, Ombeline Hamburger, Matthias Leonti, Marco Almanza, Giovanna Gertsch, Jürg iScience Article Globally, more than six million people are infected with Trypanosoma cruzi, the causative protozoan parasite of the vector-borne Chagas disease (CD). We conducted a cross-sectional ethnopharmacological field study in Bolivia among different ethnic groups where CD is hyperendemic. A total of 775 extracts of botanical drugs used in Bolivia in the context of CD and botanical drugs from unrelated indications from the Mediterranean De Materia Medica compiled by Dioscorides two thousand years ago were profiled in a multidimensional assay uncovering different antichagasic natural product classes. Intriguingly, the phylobioactive anthraquinone hotspot matched the antichagasic activity of Senna chloroclada, the taxon with the strongest ethnomedical consensus for treating CD among the Izoceño-Guaraní. Testing common 9,10-anthracenedione derivatives in T. cruzi cellular infection assays demarcates hydroxyanthraquinone as a potential antichagasic lead scaffold. Our study systematically uncovers in vitro antichagasic phylogenetic hotspots in the plant kingdom as a potential resource for drug discovery based on ethnopharmacological hypotheses. Elsevier 2021-03-15 /pmc/articles/PMC8040286/ /pubmed/33870129 http://dx.doi.org/10.1016/j.isci.2021.102310 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Salm, Andrea
Krishnan, Sandhya R.
Collu, Marta
Danton, Ombeline
Hamburger, Matthias
Leonti, Marco
Almanza, Giovanna
Gertsch, Jürg
Phylobioactive hotspots in plant resources used to treat Chagas disease
title Phylobioactive hotspots in plant resources used to treat Chagas disease
title_full Phylobioactive hotspots in plant resources used to treat Chagas disease
title_fullStr Phylobioactive hotspots in plant resources used to treat Chagas disease
title_full_unstemmed Phylobioactive hotspots in plant resources used to treat Chagas disease
title_short Phylobioactive hotspots in plant resources used to treat Chagas disease
title_sort phylobioactive hotspots in plant resources used to treat chagas disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040286/
https://www.ncbi.nlm.nih.gov/pubmed/33870129
http://dx.doi.org/10.1016/j.isci.2021.102310
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