Cargando…

Homoharringtonine inhibited breast cancer cells growth via miR-18a-3p/AKT/mTOR signaling pathway

Homoharringtonine (HHT), a natural alkaloid derived from the cephalotaxus, exhibited its anti-cancer effects in hematological malignancies clinically. However, its pesticide effects and mechanisms in treating solid tumors remain unclear. In this study, we found that HHT was capable of inhibiting tum...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Li-bin, Wang, Dan-ni, Wu, Li-gang, Cao, Jia, Tian, Jin-hai, Liu, Rong, Ma, Rong, Yu, Jing-jing, Wang, Jia, Huang, Qi, Xiong, Wen-yong, Zhang, Xu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8040299/ https://www.ncbi.nlm.nih.gov/pubmed/33867824 http://dx.doi.org/10.7150/ijbs.44907

Ejemplares similares

MiR-146b inhibits autophagy in prostate cancer by targeting the PTEN/Akt/mTOR signaling pathway
por: Gao, Song, et al.
Publicado: (2018)

Inhibition of the AKT/mTOR pathway negatively regulates PTEN expression via miRNAs: Effect of Akt/mTOR inhibition on PTEN expression
por: Wan, Linyan, et al.
Publicado: (2022)

miR-122 and miR-199 synergistically promote autophagy in oral lichen planus by targeting the Akt/mTOR pathway
por: Wang, Liang, et al.
Publicado: (2019)

Correction: MiR-146b inhibits autophagy in prostate cancer through affecting PTEN/AKT/mTOR signaling pathway
por: Gao, Song, et al.
Publicado: (2019)

MiR-370 sensitizes chronic myeloid leukemia K562 cells to homoharringtonine by targeting Forkhead box M1
por: Zhou, MinRan, et al.
Publicado: (2013)

Homoharringtonine inhibits fibroblasts proliferation, extracellular matrix production and reduces surgery-induced knee arthrofibrosis via PI3K/AKT/mTOR pathway-mediated apoptosis
por: Sun, Yu, et al.
Publicado: (2021)

Dihydroartemisinin Induces Endothelial Cell Autophagy through Suppression of the Akt/mTOR Pathway
por: Liu, Jing, et al.
Publicado: (2019)

Akt1 Enhances CA916798 Expression through mTOR Pathway
por: Wang, Yu-Liang, et al.
Publicado: (2013)

FAM83A as a Potential Biological Marker Is Regulated by miR-206 to Promote Cervical Cancer Progression Through PI3K/AKT/mTOR Pathway
por: Rong, Li, et al.
Publicado: (2020)

Dichloroacetate Overcomes Oxaliplatin Chemoresistance in Colorectal Cancer through the miR-543/PTEN/Akt/mTOR Pathway
por: Liang, Yu, et al.
Publicado: (2019)

HDAC6, modulated by miR-206, promotes endometrial cancer progression through the PTEN/AKT/mTOR pathway
por: Zheng, Yawen, et al.
Publicado: (2020)

Exosomes derived from miR-26a-modified MSCs promote axonal regeneration via the PTEN/AKT/mTOR pathway following spinal cord injury
por: Chen, Yuyong, et al.
Publicado: (2021)

Enhancing nasopharyngeal carcinoma cell radiosensitivity by suppressing AKT/mTOR via CENP-N knockdown
por: Wu, Li-Zhi, et al.
Publicado: (2023)

miR-451a is underexpressed and targets AKT/mTOR pathway in papillary thyroid carcinoma
por: Minna, Emanuela, et al.
Publicado: (2016)

miR-29c Increases Protein Synthesis in Skeletal Muscle Independently of AKT/mTOR
por: Alves, Paula Ketilly Nascimento, et al.
Publicado: (2022)

MiR-30e-3p inhibits gastric cancer development by negatively regulating THO complex 2 and PI3K/AKT/mTOR signaling
por: Gu, Xiao-Jing, et al.
Publicado: (2022)

Arbutin suppresses osteosarcoma progression via miR‐338‐3p/MTHFD1L and inactivation of the AKT/mTOR pathway
por: Wang, Cheng‐Qun, et al.
Publicado: (2020)

Insulin Promotes Glucose Consumption via Regulation of miR-99a/mTOR/PKM2 Pathway
por: Li, Wei, et al.
Publicado: (2013)

LncRNA MEG3 inhibits rheumatoid arthritis through miR‐141 and inactivation of AKT/mTOR signalling pathway
por: Li, Guoqing, et al.
Publicado: (2019)

Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Regulates Neurite Outgrowth Through the Activation of Akt/mTOR and Erk/mTOR Signaling Pathways
por: Wen, Wen, et al.
Publicado: (2020)

miR-99a-5p: A Potential New Therapy for Atherosclerosis by Targeting mTOR and Then Inhibiting NLRP3 Inflammasome Activation and Promoting Macrophage Autophagy
por: Wang, Gang, et al.
Publicado: (2022)

Targeted Disruption of miR-17-92 Impairs Mouse Spermatogenesis by Activating mTOR Signaling Pathway
por: Xie, Raoying, et al.
Publicado: (2016)

Correction: miR-451a is underexpressed and targets AKT/mTOR pathway in papillary thyroid carcinoma
por: Minna, Emanuela, et al.
Publicado: (2018)

Suppression of Akt-mTOR pathway rescued the social behavior in Cntnap2-deficient mice
por: Xing, Xiaoliang, et al.
Publicado: (2019)

The Paradox of Akt-mTOR Interactions
por: Vadlakonda, Lakshmipathi, et al.
Publicado: (2013)

miR-138 Reduces the Dysfunction of T Follicular Helper Cells in Osteosarcoma via the PI3K/Akt/mTOR Pathway by Targeting PDK1
por: Jiang, Baoen, et al.
Publicado: (2021)

The Roles of Autophagy, Mitophagy, and the Akt/mTOR Pathway in the Pathogenesis of Chronic Rhinosinusitis with Nasal Polyps
por: Wang, Chen, et al.
Publicado: (2022)

miR‐126 reduces trastuzumab resistance by targeting PIK3R2 and regulating AKT/mTOR pathway in breast cancer cells
por: Fu, Rao, et al.
Publicado: (2020)

Homoharringtonine and omacetaxine for myeloid hematological malignancies
por: Lü, Shuqing, et al.
Publicado: (2014)

Ursodeoxycholic acid inhibits intimal hyperplasia, vascular smooth muscle cell excessive proliferation, migration via blocking miR-21/PTEN/AKT/mTOR signaling pathway
por: Huang, Rong, et al.
Publicado: (2020)

Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway
por: Li, Xiao-yu, et al.
Publicado: (2017)

miR-196b regulates gastric cancer cell proliferation and invasion via PI3K/AKT/mTOR signaling pathway
por: LI, NA, et al.
Publicado: (2016)

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt
por: Tiedemann, Kerstin, et al.
Publicado: (2017)

The Natural Compound Homoharringtonine Presents Broad Antiviral Activity In Vitro and In Vivo
por: Dong, Hui-Jun, et al.
Publicado: (2018)

LncRNA NORAD Promotes Proliferation And Inhibits Apoptosis Of Gastric Cancer By Regulating miR-214/Akt/mTOR Axis
por: Tao, Wei, et al.
Publicado: (2019)

The AKT/mTOR Signaling Pathway Was Mediated through the LINC00514/miR-28-5p/TRIM44 Axis
por: Wu, Lin, et al.
Publicado: (2022)

CircCASC15-miR-100-mTOR may influence the cervical cancer radioresistance
por: Yao, Tingting, et al.
Publicado: (2022)

MiR-1906 Attenuates Neuropathic Pain in Rats by Regulating the TLR4/mTOR/ Akt Signaling Pathway
por: Fang, Xianhai, et al.
Publicado: (2019)

Neuroligin 3 Regulates Dendritic Outgrowth by Modulating Akt/mTOR Signaling
por: Xu, Jing, et al.
Publicado: (2019)

Three kinds of treatment with Homoharringtonine, Hydroxychloroquine or shRNA and their combination against coronavirus PEDV in vitro
por: Li, Cui-Cui, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_4d3hfkhb6kju5ngd50hhp325rn